{"id":"peplomycin","rwe":[{"pmid":"35866907","year":"2022","title":"Successful treatment of squamous cell carcinoma on the lip with continuous intra-arterial peplomycin infusion chemotherapy: a report of 27 cases.","finding":"","journal":"European journal of dermatology : EJD","studyType":"Clinical Study"},{"pmid":"32070653","year":"2020","title":"Preoperative intra-arterial chemotherapy with docetaxel, cisplatin, and peplomycin combined with intravenous chemotherapy using 5-fluorouracil for oral squamous cell carcinoma.","finding":"","journal":"International journal of oral and maxillofacial surgery","studyType":"Clinical Study"},{"pmid":"30881827","year":"2019","title":"Squamous Cell Carcinoma following Epidermoid Cyst in the Buttock.","finding":"","journal":"Plastic and reconstructive surgery. Global open","studyType":"Clinical Study"},{"pmid":"30464999","year":"2018","title":"Structural changes of Zn(II)bleomycin complexes when bound to DNA hairpins containing the 5'-GT-3' and 5'-GC-3' binding sites studied through NMR spectroscopy.","finding":"","journal":"Magnetochemistry (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"30088306","year":"2018","title":"Direct Observation of H3-H4 Octasome by High-Speed AFM.","finding":"","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"}],"tags":[{"label":"peplomycin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antibiotics, Antineoplastic","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"bleomycin pep","offLabel":[],"synonyms":["peplomycin","Bleomycin PEP","pepleomycin","peplomycin sulfate","NK631","NK-631"],"timeline":[],"approvals":[],"brandName":"Bleomycin Pep","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"peplomycin","explanation":"Imagine your cells are like factories that make new parts. Peplomycin is like a machine that breaks down the factory's blueprint, making it impossible for the factory to produce new parts. This ultimately leads to the factory shutting down, or in this case, the cell dying.","oneSentence":"Peplomycin works by binding to DNA and inhibiting the synthesis of DNA and RNA, ultimately leading to cell death.","technicalDetail":"Peplomycin binds to the minor groove of DNA, causing intercalation and subsequent inhibition of topoisomerase II and DNA polymerase, leading to DNA strand breaks and cell death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2965","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=PEPLOMYCIN","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PEPLOMYCIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:16:58.568762","biosimilars":[],"competitors":[],"genericName":"peplomycin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT01564277","phase":"PHASE2","title":"Rasburicase and Allopurinol in Treating Patients With Hematologic Malignancies","status":"TERMINATED","sponsor":"Roswell Park Cancer Institute","startDate":"2011-09-29","conditions":["Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities","Adult Acute Myeloid Leukemia With Del(5q)","Adult Acute Myeloid Leukemia With Inv(16)(p13;q22)","Adult Acute Myeloid Leukemia With t(15;17)(q22;q12)","Adult Acute Myeloid Leukemia With t(16;16)(p13;q22)","Adult Acute Myeloid Leukemia With t(8;21)(q22;q22)","Blastic Phase Chronic Myelogenous Leukemia","Contiguous Stage II Adult Burkitt Lymphoma","de Novo Myelodysplastic Syndromes","Noncontiguous Stage II Adult Burkitt Lymphoma","Previously Treated Myelodysplastic Syndromes","Recurrent Adult Acute Lymphoblastic Leukemia","Recurrent Adult Acute Myeloid Leukemia","Recurrent Adult Burkitt Lymphoma","Stage I Adult Burkitt Lymphoma","Stage III Adult Burkitt Lymphoma","Stage IV Adult Burkitt Lymphoma","Untreated Adult Acute Lymphoblastic Leukemia","Untreated Adult Acute Myeloid Leukemia"],"enrollment":24,"completionDate":"2016-05-28"},{"nctId":"NCT00057811","phase":"PHASE2","title":"Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma","status":"COMPLETED","sponsor":"Children's Oncology Group","startDate":"2004-06","conditions":["Childhood Burkitt Lymphoma","Childhood Diffuse Large Cell Lymphoma","Childhood Immunoblastic Large Cell Lymphoma","Stage I Childhood Large Cell Lymphoma","Stage I Childhood Small Noncleaved Cell Lymphoma","Stage II Childhood Large Cell Lymphoma","Stage II Childhood Small Noncleaved Cell Lymphoma","Stage III Childhood Large Cell Lymphoma","Stage III Childhood Small Noncleaved Cell Lymphoma","Stage IV Childhood Large Cell Lymphoma","Stage IV Childhood Small Noncleaved Cell Lymphoma","Untreated Childhood Acute Lymphoblastic Leukemia"],"enrollment":97,"completionDate":"2014-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"56H9L80NIZ","CHEBI":"CHEBI:135909","INN_ID":"4833","UMLSCUI":"C0135981","ChEMBL_ID":"CHEMBL3990196","KEGG_DRUG":"D02063","PUBCHEM_CID":"6852373","SECONDARY_CAS_RN":"70384-29-1","MESH_DESCRIPTOR_UI":"D017663"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Apr 1","pmid":"35866907","title":"Successful treatment of squamous cell carcinoma on the lip with continuous intra-arterial peplomycin infusion chemotherapy: a report of 27 cases.","journal":"European journal of dermatology : EJD"},{"date":"2020 Aug","pmid":"32070653","title":"Preoperative intra-arterial chemotherapy with docetaxel, cisplatin, and peplomycin combined with intravenous chemotherapy using 5-fluorouracil for oral squamous cell carcinoma.","journal":"International journal of oral and maxillofacial surgery"},{"date":"2019 Feb","pmid":"30881827","title":"Squamous Cell Carcinoma following Epidermoid Cyst in the Buttock.","journal":"Plastic and reconstructive surgery. Global open"},{"date":"2018","pmid":"30464999","title":"Structural changes of Zn(II)bleomycin complexes when bound to DNA hairpins containing the 5'-GT-3' and 5'-GC-3' binding sites studied through NMR spectroscopy.","journal":"Magnetochemistry (Basel, Switzerland)"},{"date":"2018 Oct 26","pmid":"30088306","title":"Direct Observation of H3-H4 Octasome by High-Speed AFM.","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bleomycin Pep, also known as Peplomycin, is a peplomycin class small molecule drug. Its exact target is unknown, but it is used to treat certain types of cancer. The commercial status of Peplomycin is unclear, and it may be patented or have generic manufacturers. Key safety considerations include its potential to cause pulmonary toxicity. Further research is needed to fully understand its pharmacokinetics and clinical applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}