{"id":"pentoxyverine","rwe":[{"pmid":"39179055","year":"2025","title":"20S-Ginsenoside Rh2, the major bioactive saponin in Panax notoginseng flowers, ameliorates cough by inhibition of NaV1.7 and TRPV1 channel currents and downregulation of TRPV1 expression.","finding":"","journal":"Journal of ethnopharmacology","studyType":"Clinical Study"},{"pmid":"35911969","year":"2022","title":"The Effectiveness of Wogonin on Treating Cough Mice With Mycoplasma Pneumoniae Infection.","finding":"","journal":"Frontiers in molecular biosciences","studyType":"Clinical Study"},{"pmid":"35449547","year":"2022","title":"Exploring Potential Regulatory Anesthetic Drugs Based on RNA Binding Protein and Constructing CESC Prognosis Model: A Study Based on TCGA Database.","finding":"","journal":"Frontiers in surgery","studyType":"Clinical Study"},{"pmid":"34227920","year":"2021","title":"Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration.","finding":"","journal":"Bioengineered","studyType":"Clinical Study"},{"pmid":"32164969","year":"2020","title":"Carbetapentane citrate.","finding":"","journal":"Profiles of drug substances, excipients, and related methodology","studyType":"Clinical Study"}],"_fda":{"id":"451b96c1-db6d-b777-e063-6394a90a7bef","set_id":"fc8f1807-d344-ccc2-e053-6294a90a5089","openfda":{"nui":["N0000175739","N0000175729","N0000175790","M0023046","N0000193956","N0000008867","N0000009560"],"upc":["8806427035326"],"unii":["362O9ITL9D","3G6A5W338E","V1Q0O9OJ9Z","495W7451VQ","4SH0MFJ5HJ","04JA59TNSJ"],"route":["ORAL"],"spl_id":["451b96c1-db6d-b777-e063-6394a90a7bef"],"brand_name":["PANCOLD A"],"spl_set_id":["fc8f1807-d344-ccc2-e053-6294a90a5089"],"package_ndc":["51352-189-73","51352-189-75"],"product_ndc":["51352-189"],"generic_name":["ACETAMINOPHEN, GUAIFENESIN, PENTOXYVERINE CITRATE, PHENYLPEHRINE HYDCROCHLORIDE, CHLORPHENIRAMINE MALEATE, CAFFEINE ANHYDROUS"],"product_type":["HUMAN OTC DRUG"],"pharm_class_cs":["Xanthines [CS]"],"pharm_class_pe":["Central Nervous System Stimulation [PE]","Decreased Respiratory Secretion Viscosity [PE]","Increased Respiratory Secretions [PE]"],"substance_name":["ACETAMINOPHEN","CAFFEINE","CHLORPHENIRAMINE MALEATE","GUAIFENESIN","PENTOXYVERINE CITRATE","PHENYLEPHRINE HYDROCHLORIDE"],"pharm_class_epc":["Central Nervous System Stimulant [EPC]","Methylxanthine [EPC]","Expectorant [EPC]"],"manufacturer_name":["DONGWHA PHARM. 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Symptoms may include: skin reddening blisters rash If a skin reaction occurs, stop use and seek medical help right away. Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly."],"ask_doctor":["ASK A DOCTOR Ask a doctor before use if you have liver disease heart disease high blood pressure thyroid disease diabetes trouble urinating due to enlarge prostate gland persistent or chronic cough such as occurs with smoking, asthma or emphysema cough that occurs with too much phlegm (mucus) glaucoma (eye pain, blurred vision) weak body high fever"],"do_not_use":["DO NOT USE Do not use if you ever had an allergic reaction to this product or any of its ingredients with any other drug containing acetaminophen. If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist. If you are taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains MAOI, ask a doctor or pharmacist before taking this product. If you are taking expectorants, other cold drugs, antipyretic-analgesics, sedatives, oral drugs containing antihistamines (oral drugs for rhinitis, motion sickness drugs, and allergy drugs)"],"overdosage":["OVERDOSAGE Overdose warning: In case of overdose, get medical help or contact a Poison Control Center right away. Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptom."],"effective_time":"20251231","active_ingredient":["ACTIVE INGREDIENTS Active ingredients (in each 30 mL bottle) Acetaminophen 300 mg Guaifenesin 80 mg Pentoxyverine citrate 15 mg Phenylephrine Hydrochloride 10 mg Chlorpheniramine maleate 2.5 mg Caffeine 30 mg"],"inactive_ingredient":["INACTIVE INGREDIENTS Inactive Ingredients: : alcohol, citric acid monohydrate, edetate disodium, fructooligosaccharide, lemon flavor, orange flavor, propylene glycol, sodium citrate, sucralose, water"],"storage_and_handling":["STORAGE AND HANDLING Other nformation store at room temperature between 15°-25°C (59°-77°F) and avoid direct sunlight"],"indications_and_usage":["INDICATIONS & USAGE Uses temporarily relieves these common cold symptoms: runny nose & sneezing nasal congestion sore throat cough phlegm chills fever headache joint pain muscle pain"],"dosage_and_administration":["DOSAGE & ADMINISTRATION Directions do not take more than directed (see overdose warning) Adults: Take 1 bottle (30mL) three times a day, 30 minutes after meal. Children and infants: Do not administer. Ask a doctor."],"spl_product_data_elements":["PANCOLD A Acetaminophen, Guaifenesin, Pentoxyverine citrate, Phenylpehrine Hydcrochloride, Chlorpheniramine Maleate, Caffeine Anhydrous PENTOXYVERINE CITRATE PENTOXYVERINE SODIUM CITRATE SUCRALOSE ACETAMINOPHEN ACETAMINOPHEN GUAIFENESIN GUAIFENESIN CHLORPHENIRAMINE MALEATE CHLORPHENIRAMINE PROPYLENE GLYCOL CITRIC ACID MONOHYDRATE CAFFEINE CAFFEINE EDETATE DISODIUM ALCOHOL PHENYLEPHRINE HYDROCHLORIDE PHENYLEPHRINE SACCHARUM OFFICINARUM STEM FRUCTOOLIGOSACCHARIDES WATER ORANGE LEMON Light yellowish clear oral liquid with orange-lemon flavor."],"pregnancy_or_breast_feeding":["PREGNANCY OR BREAST FEEDING If pregnant or breast-feeding, ask a health professional before use."],"keep_out_of_reach_of_children":["KEEP OUT OF REACH OF CHILDREN Keep out of reach of children."],"dosage_and_administration_table":["<table border=\"0\" width=\"100%\"><tbody><tr><td>Adults:</td><td>Take 1 bottle (30mL) three times a day, 30 minutes after meal.</td></tr><tr><td>Children and infants:</td><td>Do not administer. 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