{"id":"pentoxifylline-plus-metadoxine","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Tremor"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pentoxifylline is a methylxanthine derivative that decreases blood viscosity, improves erythrocyte deformability, and enhances tissue oxygenation by reducing platelet aggregation and increasing blood flow. Metadoxine (pyridoxine pyroglutamate) acts as a cofactor in cellular metabolism and supports hepatic detoxification pathways. The combination targets both microcirculatory impairment and metabolic dysfunction.","oneSentence":"Pentoxifylline improves blood flow and reduces blood viscosity while metadoxine enhances cellular metabolism and liver function, together addressing microcirculatory dysfunction and metabolic support.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:35:50.687Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Alcoholic liver disease"},{"name":"Hepatic cirrhosis with microcirculatory dysfunction"}]},"trialDetails":[{"nctId":"NCT02161653","phase":"PHASE4","title":"Metadoxine as a Therapy for Severe Alcoholic Hepatitis","status":"COMPLETED","sponsor":"Hospital General de Mexico","startDate":"2010-04","conditions":"Severe Alcoholic Hepatitis","enrollment":135}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Pentoxifylline plus Metadoxine","genericName":"Pentoxifylline plus Metadoxine","companyName":"Hospital General de Mexico","companyId":"hospital-general-de-mexico","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pentoxifylline improves blood flow and reduces blood viscosity while metadoxine enhances cellular metabolism and liver function, together addressing microcirculatory dysfunction and metabolic support. Used for Alcoholic liver disease, Hepatic cirrhosis with microcirculatory dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}