{"id":"penthienate","rwe":[],"tags":[{"label":"penthienate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A03AB04","category":"atc"},{"label":"Active","category":"status"},{"label":"Gastric spasm","category":"indication"},{"label":"Peptic ulcer","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"monodral","offLabel":[],"synonyms":["penthienate bromide","monodral","penthienate"],"timeline":[],"approvals":[],"brandName":"Monodral","ecosystem":[{"indication":"Gastric spasm","otherDrugs":[],"globalPrevalence":null},{"indication":"Peptic ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":64000000}],"mechanism":{"modality":"Small Molecule","drugClass":"penthienate","explanation":"Think of it like a volume control for your stomach muscles. When you eat, your stomach muscles contract to mix food with digestive juices. Monodral helps slow down these muscle contractions, giving your stomach a break and reducing symptoms like cramps and nausea.","oneSentence":"Monodral works by inhibiting the action of acetylcholine at muscarinic receptors in the gastrointestinal tract.","technicalDetail":"Monodral exerts its effects by competitively antagonizing muscarinic acetylcholine receptors, specifically M1 and M3 subtypes, which are involved in the regulation of gastrointestinal smooth muscle contraction."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2093","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=penthienate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:17:14.517382","biosimilars":[],"competitors":[{"drugName":"glycopyrronium bromide","drugSlug":"glycopyrronium-bromide","fdaApproval":"1961-08-11","relationship":"same-class"},{"drugName":"oxyphenonium","drugSlug":"oxyphenonium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"propantheline","drugSlug":"propantheline","fdaApproval":"1953-04-02","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methanthelinium","drugSlug":"methanthelinium","fdaApproval":"1951-07-03","relationship":"same-class"},{"drugName":"tridihexethyl","drugSlug":"tridihexethyl","fdaApproval":"1954-09-15","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"isopropamide","drugSlug":"isopropamide","fdaApproval":"1957-10-09","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"hexocyclium","drugSlug":"hexocyclium","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"mepenzolate","drugSlug":"mepenzolate","fdaApproval":"1956-11-14","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"diphemanil","drugSlug":"diphemanil","fdaApproval":"1976-05-17","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"penthienate","indications":{"approved":[{"name":"Gastric spasm","source":"DrugCentral","snomedId":196754001,"regulator":"FDA"},{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glycopyrronium-bromide","brandName":"glycopyrronium bromide","genericName":"glycopyrronium bromide","approvalYear":"1961","relationship":"same-class"},{"drugId":"oxyphenonium","brandName":"oxyphenonium","genericName":"oxyphenonium","approvalYear":"","relationship":"same-class"},{"drugId":"propantheline","brandName":"propantheline","genericName":"propantheline","approvalYear":"1953","relationship":"same-class"},{"drugId":"methanthelinium","brandName":"methanthelinium","genericName":"methanthelinium","approvalYear":"1951","relationship":"same-class"},{"drugId":"tridihexethyl","brandName":"tridihexethyl","genericName":"tridihexethyl","approvalYear":"1954","relationship":"same-class"},{"drugId":"isopropamide","brandName":"isopropamide","genericName":"isopropamide","approvalYear":"1957","relationship":"same-class"},{"drugId":"hexocyclium","brandName":"hexocyclium","genericName":"hexocyclium","approvalYear":"","relationship":"same-class"},{"drugId":"mepenzolate","brandName":"mepenzolate","genericName":"mepenzolate","approvalYear":"1956","relationship":"same-class"},{"drugId":"diphemanil","brandName":"diphemanil","genericName":"diphemanil","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001741","UNII":"6LCT38OJV9","CHEBI":"CHEBI:135447","UMLSCUI":"C0301375","ChEMBL_ID":"CHEMBL2110700","KEGG_DRUG":"D07081","DRUGBANK_ID":"DB13695","PUBCHEM_CID":"6067","SNOMEDCT_US":"19524002","SECONDARY_CAS_RN":"60-44-6","MESH_SUPPLEMENTAL_RECORD_UI":"C102258"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"A03AB04","allCodes":["A03AB04"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Monodral is a small molecule with anticholinergic properties, similar to atropine. It is used to treat conditions such as peptic ulcer and dyspepsia by reducing gastric motility and secretion.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}