{"id":"pentapiperium-metilsulfate","rwe":[{"pmid":"39429427","year":"2024","title":"Multiple System Atrophy Masquerading as Drug-Resistant Orthostatic Hypotension.","finding":"","journal":"Cureus","studyType":"Clinical Study"},{"pmid":"26016487","year":"2016","title":"Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.","finding":"","journal":"Cephalalgia : an international journal of headache","studyType":"Clinical Study"},{"pmid":"24357101","year":"2014","title":"A sensitive LC-MS/MS method for simultaneous determination of R-bambuterol and its active metabolite R-terbutaline in human plasma and urine with application to a clinical pharmacokinetic study.","finding":"","journal":"Biomedical chromatography : BMC","studyType":"Clinical Study"},{"pmid":"20550853","year":"2009","title":"[Neostigmine test for the diagnosis of congenital hypertrofic pyloric stenosis during the last 50 years].","finding":"","journal":"Revista medica del Instituto Mexicano del Seguro Social","studyType":"Clinical Study"},{"pmid":"12664248","year":"2003","title":"Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy.","finding":"","journal":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Peptic ulcer","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pentapiperium","offLabel":[],"synonyms":["pentapiperium metilsulfate","pentapiperium methylsulfate","pentapiperium","pentapiperide methylsulphate","pentapiperium metilsulphate"],"timeline":[],"approvals":[],"brandName":"Pentapiperium","ecosystem":[{"indication":"Peptic ulcer","otherDrugs":[{"name":"algeldrate","slug":"algeldrate","company":"Sanofi Aventis Us"},{"name":"almasilate","slug":"almasilate","company":""},{"name":"chlordiazepoxide","slug":"chlordiazepoxide","company":"Valeant Pharm Intl"},{"name":"dexlansoprazole","slug":"dexlansoprazole","company":"Takeda Pharms Usa"}],"globalPrevalence":64000000}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your stomach lining is like a delicate skin that can get irritated and inflamed. Histamine is a chemical that can make this irritation worse, causing stomach acid to flow and create ulcers. Pentapiperium blocks histamine's action, giving your stomach lining a chance to heal and reducing the risk of further damage.","oneSentence":"Pentapiperium works by inhibiting the action of histamine on the stomach lining, reducing acid production and promoting healing of peptic ulcers.","technicalDetail":"Pentapiperium exerts its effects by competitively inhibiting histamine H2 receptors in the gastric parietal cells, thereby reducing gastric acid secretion and promoting ulcer healing."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/5073","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pentapiperium metilsulfate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:16:09.457174","biosimilars":[],"competitors":[],"genericName":"pentapiperium metilsulfate","indications":{"approved":[{"name":"Peptic ulcer","source":"DrugCentral","snomedId":13200003,"regulator":"FDA","usPrevalence":null,"globalPrevalence":64000000,"prevalenceMethod":"curated","prevalenceSource":"Aliment Pharmacol Ther, 2009 (PMID:19220208)"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001769","UNII":"Y8B7PF4062","CHEBI":"CHEBI:134707","INN_ID":"3097","UMLSCUI":"C0770470","ChEMBL_ID":"CHEMBL2107046","KEGG_DRUG":"D05418","PUBCHEM_CID":"71367","SNOMEDCT_US":"43541002","SECONDARY_CAS_RN":"26372-86-1"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":11,"therapeuticAreas":["Dermatology"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Sep","pmid":"39429427","title":"Multiple System Atrophy Masquerading as Drug-Resistant Orthostatic Hypotension.","journal":"Cureus"},{"date":"2016 Mar","pmid":"26016487","title":"Diffuse cerebrovascular dilation: Case report of amezinium metilsulfate-induced reversible cerebral vasoconstriction syndrome.","journal":"Cephalalgia : an international journal of headache"},{"date":"2014 Jul","pmid":"24357101","title":"A sensitive LC-MS/MS method for simultaneous determination of R-bambuterol and its active metabolite R-terbutaline in human plasma and urine with application to a clinical pharmacokinetic study.","journal":"Biomedical chromatography : BMC"},{"date":"2009 Sep-Oct","pmid":"20550853","title":"[Neostigmine test for the diagnosis of congenital hypertrofic pyloric stenosis during the last 50 years].","journal":"Revista medica del Instituto Mexicano del Seguro Social"},{"date":"2003 Feb","pmid":"12664248","title":"Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy.","journal":"Clinical autonomic research : official journal of the Clinical Autonomic Research Society"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Pentapiperium (pentapiperium metilsulfate) is a small molecule drug with unknown drug class and target. It is used to treat peptic ulcers, a condition characterized by stomach or duodenal ulcers. The commercial status of pentapiperium is unclear, and it may be patented or have generic manufacturers. Further research is needed to determine its key safety considerations and pharmacokinetic properties. As a pharma professional, it is essential to verify the current ownership and FDA approval status of pentapiperium.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}