{"id":"pentaerithrityl-tetranitrate","rwe":[{"pmid":"39554591","year":"2024","title":"Pentaerithrityl tetranitrate (PETN) for prevention of fetal growth restriction in pregnancy: A systematic review and meta-analysis.","finding":"","journal":"European journal of obstetrics & gynecology and reproductive biology: X","studyType":"Clinical Study"},{"pmid":"31521118","year":"2019","title":"Does Pentaerytrithyltetranitrate reduce fetal growth restriction in pregnancies complicated by uterine mal-perfusion? 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Nitric oxide is like a traffic cop that tells the blood vessels to relax and let more blood flow through. This helps to improve blood flow and reduce blood pressure.","oneSentence":"Pentanitrine works by releasing nitric oxide, which relaxes blood vessels and improves blood flow.","technicalDetail":"Pentanitrine is a prodrug that releases nitric oxide through enzymatic degradation, leading to the activation of guanylate cyclase and an increase in cyclic guanosine monophosphate (cGMP) levels, resulting in smooth muscle relaxation and vasodilation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2087","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=pentaerithrityl%20tetranitrate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pentaerithrityl tetranitrate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:15:58.910051","biosimilars":[],"competitors":[{"drugName":"glyceryl trinitrate","drugSlug":"glyceryl-trinitrate","fdaApproval":"1981-05-28","relationship":"same-class"},{"drugName":"isosorbide dinitrate","drugSlug":"isosorbide-dinitrate","fdaApproval":"1968-01-16","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"isosorbide mononitrate","drugSlug":"isosorbide-mononitrate","fdaApproval":"1991-12-30","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"pentaerithrityl tetranitrate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"glyceryl-trinitrate","brandName":"glyceryl trinitrate","genericName":"glyceryl trinitrate","approvalYear":"1981","relationship":"same-class"},{"drugId":"isosorbide-dinitrate","brandName":"isosorbide dinitrate","genericName":"isosorbide dinitrate","approvalYear":"1968","relationship":"same-class"},{"drugId":"isosorbide-mononitrate","brandName":"isosorbide mononitrate","genericName":"isosorbide mononitrate","approvalYear":"1991","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT03669185","phase":"PHASE3","title":"Pentaerithrityl Tetranitrate (PETN) for Secondary Prevention of Intrauterine Growth Restriction","status":"UNKNOWN","sponsor":"Jena University Hospital","startDate":"2017-07-26","conditions":["Fetal Growth Retardation","Pregnancy Related","Intrauterine Growth Restriction"],"enrollment":324,"completionDate":"2021-10-31"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000146783","NDDF":"000686","UNII":"10L39TRG1Z","VUID":"4018459","CHEBI":"CHEBI:25879","VANDF":"4018459","INN_ID":"1455","RXNORM":"7992","UMLSCUI":"C0030858","ChEMBL_ID":"CHEMBL466659","KEGG_DRUG":"D01721","DRUGBANK_ID":"DB06154","PUBCHEM_CID":"6518","SNOMEDCT_US":"10422008","MESH_DESCRIPTOR_UI":"D010417"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"60%"},"publicationCount":27,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"C01DA05","allCodes":["C01DA05","C01DA55"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Dec","pmid":"39554591","title":"Pentaerithrityl tetranitrate (PETN) for prevention of fetal growth restriction in pregnancy: A systematic review and meta-analysis.","journal":"European journal of obstetrics & gynecology and reproductive biology: X"},{"date":"2019 Sep 14","pmid":"31521118","title":"Does Pentaerytrithyltetranitrate reduce fetal growth restriction in pregnancies complicated by uterine mal-perfusion? 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It is classified as an activator and is structurally similar to nitroglycerin.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}