{"id":"penamecillin","rwe":[{"pmid":"37909653","year":"2024","title":"Drug-induced hypoglycemia: a disproportionality analysis of the FAERS database.","finding":"","journal":"Expert opinion on drug safety","studyType":"Clinical Study"},{"pmid":"24794069","year":"2014","title":"Structure, evolution and virtual screening of NDM-1 strain from Kolkata.","finding":"","journal":"International journal of bioinformatics research and applications","studyType":"Clinical Study"},{"pmid":"17530434","year":"2007","title":"Non-prescription antibiotic use in Hungary.","finding":"","journal":"Pharmacy world & science : PWS","studyType":"Clinical Study"},{"pmid":"15214080","year":"2004","title":"Charge density and experimental electrostatic potentials of two penicillin derivatives.","finding":"","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)","studyType":"Clinical Study"},{"pmid":"9846705","year":"1998","title":"Use of antibiotics during pregnancy.","finding":"","journal":"European journal of obstetrics, gynecology, and reproductive biology","studyType":"Clinical Study"}],"tags":[{"label":"penamecillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01CE06","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"acetoxymethyl benzylpenicillanate","offLabel":[],"synonyms":["penamecillin","acetoxymethyl benzylpenicillanate","acetoxymethyl benzylpenicillinate","benzylpenicillin acetoxymethyl ester"],"timeline":[],"approvals":[],"brandName":"Acetoxymethyl Benzylpenicillanate","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"penamecillin","explanation":"Imagine the bacterial cell wall as a strong, protective shield. Penamecillin disrupts the process of building this shield, causing the bacterial cell to weaken and eventually die. This is a crucial step in treating bacterial infections.","oneSentence":"Penamecillin works by inhibiting the synthesis of the bacterial cell wall, ultimately leading to bacterial cell death.","technicalDetail":"Penamecillin exerts its antibacterial effect by inhibiting the transpeptidase enzyme, which is essential for the cross-linking of peptidoglycan layers in the bacterial cell wall, ultimately leading to cell lysis and death."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2077","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PENAMECILLIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:15:37.795138","biosimilars":[],"competitors":[{"drugName":"benzylpenicillin","drugSlug":"benzylpenicillin","fdaApproval":"1947-02-06","relationship":"same-class"},{"drugName":"phenoxymethylpenicillin","drugSlug":"phenoxymethylpenicillin","fdaApproval":"1958-01-13","relationship":"same-class"},{"drugName":"benzathine benzylpenicillin","drugSlug":"benzathine-benzylpenicillin","fdaApproval":"1952-06-27","relationship":"same-class"},{"drugName":"procaine benzylpenicillin","drugSlug":"procaine-benzylpenicillin","fdaApproval":"1948-04-26","relationship":"same-class"}],"genericName":"penamecillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"benzylpenicillin","brandName":"benzylpenicillin","genericName":"benzylpenicillin","approvalYear":"1947","relationship":"same-class"},{"drugId":"phenoxymethylpenicillin","brandName":"phenoxymethylpenicillin","genericName":"phenoxymethylpenicillin","approvalYear":"1958","relationship":"same-class"},{"drugId":"benzathine-benzylpenicillin","brandName":"benzathine benzylpenicillin","genericName":"benzathine benzylpenicillin","approvalYear":"1952","relationship":"same-class"},{"drugId":"procaine-benzylpenicillin","brandName":"procaine benzylpenicillin","genericName":"procaine benzylpenicillin","approvalYear":"1948","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"004977","UNII":"H0P1YE5581","CHEBI":"CHEBI:131733","VANDF":"4017440","INN_ID":"2057","RXNORM":"7980","UMLSCUI":"C0070217","ChEMBL_ID":"CHEMBL2106988","KEGG_DRUG":"D05406","DRUGBANK_ID":"DB13739","PUBCHEM_CID":"10250769","SNOMEDCT_US":"323389000","IUPHAR_LIGAND_ID":"12808","MESH_SUPPLEMENTAL_RECORD_UI":"C016646"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":12,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01CE06","allCodes":["J01CE06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024 Aug","pmid":"37909653","title":"Drug-induced hypoglycemia: a disproportionality analysis of the FAERS database.","journal":"Expert opinion on drug safety"},{"date":"2014","pmid":"24794069","title":"Structure, evolution and virtual screening of NDM-1 strain from Kolkata.","journal":"International journal of bioinformatics research and applications"},{"date":"2007 Dec","pmid":"17530434","title":"Non-prescription antibiotic use in Hungary.","journal":"Pharmacy world & science : PWS"},{"date":"2004 Jun 21","pmid":"15214080","title":"Charge density and experimental electrostatic potentials of two penicillin derivatives.","journal":"Chemistry (Weinheim an der Bergstrasse, Germany)"},{"date":"1998 Oct","pmid":"9846705","title":"Use of antibiotics during pregnancy.","journal":"European journal of obstetrics, gynecology, and reproductive biology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Penamecillin, also known as Acetoxymethyl Benzylpenicillanate, is a small molecule antibiotic belonging to the penicillin class. Its mechanism of action involves inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death. However, due to limited available information, its target, approved indications, pharmacokinetic properties, and commercial status remain unknown. Further research is necessary to fully understand its clinical applications and safety profile. As a result, it is not possible to provide a comprehensive summary of its use in clinical practice.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}