{"id":"pemoline","rwe":[],"tags":[{"label":"pemoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sodium-dependent dopamine transporter","category":"target"},{"label":"SLC6A3","category":"gene"},{"label":"N06BA05","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Generic Available","category":"availability"},{"label":"Established","category":"status"},{"label":"Attention deficit hyperactivity disorder","category":"indication"},{"label":"Approved 1970s","category":"decade"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Central Nervous System Stimulants","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=PEMOLINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:12:50.841953+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:12:56.885885+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=PEMOLINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:12:57.194276+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1177/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:12:58.019482+00:00"}},"allNames":"pemolin","offLabel":[],"synonyms":["pemoline","azoksodon","azoxodon","azoxodone","centramin","dantromin","pemolin","pheniminooxazolidino","phenoxazole","phenylisohydantoin","phenylpseudohydantoi","fenoxazol","pemoline hydrochloride","magnesium pemoline","pemoline HCl"],"timeline":[{"date":"1975-01-27","type":"positive","source":"DrugCentral","milestone":"FDA approval"},{"date":"2000-04-19","type":"neutral","source":"FDA Orange Book","milestone":"Generic entry — 4 manufacturers approved"}],"aiSummary":"Pemoline (PEMOLINE) is a small molecule drug that targets the sodium-dependent dopamine transporter. Originally developed and currently owned by various companies, it was FDA-approved in 1975 for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Pemoline is off-patent and has multiple generic manufacturers. As a pemoline, it is a member of the central nervous system stimulant class. 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