{"id":"pegylated-filgrastim-and-lgrastim","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Bone pain"},{"rate":"10-20%","effect":"Headache"},{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Injection site reaction"},{"rate":"5-10%","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Filgrastim is a recombinant form of human granulocyte colony-stimulating factor (G-CSF), which is a naturally occurring protein that stimulates the bone marrow to produce more neutrophils. Pegylation of filgrastim increases its half-life and reduces its immunogenicity, allowing for more consistent and prolonged stimulation of neutrophil production.","oneSentence":"Pegylated filgrastim and filgrastim stimulate the production of white blood cells, specifically neutrophils, to help the body fight infection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:47:53.192Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduced febrile neutropenia in patients receiving myelosuppressive chemotherapy"},{"name":"Reduced infection risk in patients undergoing hematopoietic stem cell transplantation"}]},"trialDetails":[{"nctId":"NCT01285219","phase":"PHASE3","title":"A Study Comparing Pegylated Filgrastim and Filgrastim in Support for Chemotherapy","status":"COMPLETED","sponsor":"Chinese Academy of Medical Sciences","startDate":"2006-01","conditions":"Cancer","enrollment":337}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":142,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"pegylated filgrastim and filgrastim","genericName":"pegylated filgrastim and filgrastim","companyName":"Chinese Academy of Medical Sciences","companyId":"chinese-academy-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pegylated filgrastim and filgrastim stimulate the production of white blood cells, specifically neutrophils, to help the body fight infection. Used for Reduced febrile neutropenia in patients receiving myelosuppressive chemotherapy, Reduced infection risk in patients undergoing hematopoietic stem cell transplantation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}