{"id":"peg-4000-forlax","safety":{"commonSideEffects":[{"rate":null,"effect":"Abdominal bloating"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Flatulence"}]},"_chembl":{"chemblId":"CHEMBL2074863","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Polyethylene glycol (PEG) 4000 is a non-absorbable polymer that creates an osmotic gradient in the colon, increasing water retention in the intestinal lumen. This softens fecal matter and increases stool bulk, stimulating peristalsis and facilitating evacuation. It is not systemically absorbed and acts locally within the gastrointestinal tract.","oneSentence":"PEG 4000 is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:00.364Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Constipation"},{"name":"Bowel preparation before diagnostic procedures"}]},"trialDetails":[{"nctId":"NCT00255372","phase":"PHASE3","title":"To Determine the Effect of Forlax® Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence.","status":"COMPLETED","sponsor":"Ipsen","startDate":"2005-04","conditions":"Chronic Constipation","enrollment":88},{"nctId":"NCT00276354","phase":"PHASE4","title":"Study of Long-term Use of Forlax® in Elderly Patients With Chronic Constipation","status":"COMPLETED","sponsor":"Ipsen","startDate":"1999-12","conditions":"Constipation","enrollment":246},{"nctId":"NCT02526849","phase":"PHASE2","title":"Efficacy and Safety of Fecal Microbiota Transplantation for Slow Transit Constipation","status":"UNKNOWN","sponsor":"Jinling Hospital, China","startDate":"2015-11","conditions":"Slow Transit Constipation","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":8,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"PEG 4000 (Forlax®)","genericName":"PEG 4000 (Forlax®)","companyName":"Ipsen","companyId":"ipsen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"PEG 4000 is an osmotic laxative that draws water into the intestinal lumen to soften stool and promote bowel movements. Used for Constipation, Bowel preparation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}