{"id":"pd-1","safety":{"commonSideEffects":[{"rate":"20–30","effect":"Fatigue"},{"rate":"15–25","effect":"Diarrhea"},{"rate":"10–20","effect":"Nausea"},{"rate":"3–5","effect":"Immune-related pneumonitis"},{"rate":"2–5","effect":"Immune-related hepatitis"},{"rate":"1–3","effect":"Immune-related colitis"}]},"_chembl":{"chemblId":"CHEMBL1474985","moleculeType":"Small molecule","molecularWeight":"476.24"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PD-1 is an immune checkpoint protein that normally acts as a 'brake' on the immune system. Cancer cells exploit this by expressing PD-L1, which binds PD-1 and suppresses anti-tumor immunity. PD-1 inhibitors prevent this interaction, restoring T cell activation and enabling durable anti-tumor responses. This mechanism has proven effective across multiple solid and hematologic malignancies.","oneSentence":"PD-1 inhibitors block the programmed death-1 checkpoint on immune cells, allowing T cells to recognize and attack cancer cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:25:55.192Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced or metastatic solid tumors (specific indication under investigation in phase 3 trial)"}]},"trialDetails":[{"nctId":"NCT05768932","phase":"PHASE1","title":"BAL0891 in Patients With Advanced Solid Tumors or Relapsed or Refractory Acute Myeloid Leukemia","status":"RECRUITING","sponsor":"SillaJen, Inc.","startDate":"2022-12-14","conditions":"Advanced Solid Tumor, TNBC - Triple-Negative Breast Cancer, Gastric Cancer","enrollment":260},{"nctId":"NCT06439836","phase":"PHASE1","title":"Pembrolizumab Plus CA-4948 for the Treatment of Patients With Progressive Metastatic Urothelial Cancer Despite Prior 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