{"id":"pca-with-chlorhydrate-of-morphine","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Nausea and vomiting"},{"rate":"15-25","effect":"Drowsiness/sedation"},{"rate":"40-50","effect":"Constipation"},{"rate":"10-15","effect":"Pruritus"},{"rate":null,"effect":"Respiratory depression"},{"rate":"5-10","effect":"Hypotension"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and emotional response to pain. PCA is a delivery system that enables patients to control the timing and frequency of their analgesic doses within preset safety limits, improving pain management and patient satisfaction. This formulation is typically used in acute postoperative or acute pain settings.","oneSentence":"Morphine hydrochloride delivered via patient-controlled analgesia (PCA) allows patients to self-administer opioid doses on demand for pain relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:55.920Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain"},{"name":"Acute pain management in hospitalized patients"}]},"trialDetails":[{"nctId":"NCT02292667","phase":"PHASE3","title":"Efficacy of the Ultrasound-guided Transversus Abdominis Plane Block in Open Aortic Abdominal Aneurysm Repair Surgery","status":"UNKNOWN","sponsor":"Centre Hospitalier Universitaire de Besancon","startDate":"2015-01","conditions":"Aortic Aneurysm, Abdominal, Pain, Anesthesia, Local","enrollment":60},{"nctId":"NCT01233752","phase":"","title":"Association Between Clinical Effect of Morphine With PCA After Surgery and Pharmacogenetics","status":"COMPLETED","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2010-07","conditions":"Anesthesia, Surgery","enrollment":224}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Patient Controlled Analgesia (PCA)"],"phase":"phase_3","status":"active","brandName":"PCA with Chlorhydrate of Morphine","genericName":"PCA with Chlorhydrate of Morphine","companyName":"Centre Hospitalier Universitaire de Besancon","companyId":"centre-hospitalier-universitaire-de-besancon","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine hydrochloride delivered via patient-controlled analgesia (PCA) allows patients to self-administer opioid doses on demand for pain relief. Used for Acute postoperative pain, Acute pain management in hospitalized patients.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}