{"id":"passiflora-incarnata","safety":{"commonSideEffects":[{"rate":null,"effect":"Drowsiness"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":{"setId":"794b7e4f-b084-4aee-8c07-96bac459d698","title":"SLEEP AID (ACONITUM NAPELLUS, AESCULUS HIPPOCASTANUM, FLOS, ARSENICUM ALBUM, AVENA SATIVA, BELLADONNA, CAMPHORA, CINCHONA OFFICINALIS, COFFEA CRUDA, CYPRIPEDIUM PUBESCENS, HYOSCYAMUS NIGER, IGNATIA AMARA, KALI PHOSPHORICUM, PASSIFLORA INCARNATA, PHOSPHORUS, PULSATILLA, AND VALERIANA OFFICINALIS.) LIQUID [KING BIO INC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The plant extract acts as a mild central nervous system depressant, primarily through enhancement of GABA signaling and modulation of serotonin and dopamine pathways. These mechanisms reduce anxiety, promote relaxation, and improve sleep quality. The active constituents include harmaline, harmine, and various flavonoids that contribute to its calming properties.","oneSentence":"Passiflora incarnata contains alkaloids and flavonoids that modulate GABAergic and monoaminergic neurotransmission to produce anxiolytic and sedative effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:22:00.118Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anxiety and nervousness"},{"name":"Insomnia and sleep disturbances"},{"name":"Restlessness"}]},"trialDetails":[{"nctId":"NCT06278077","phase":"PHASE2","title":"Neurexan - a Clinical Trial in Short-Term Insomnia Patients","status":"COMPLETED","sponsor":"Biologische Heilmittel Heel GmbH","startDate":"2023-09-06","conditions":"Insomnia, Stress Reaction","enrollment":81},{"nctId":"NCT02651922","phase":"","title":"Treatment of Patients Suffering From Nervous Restlessness With PASCOFLAIR®","status":"COMPLETED","sponsor":"Pascoe Pharmazeutische Praeparate GmbH","startDate":"2014-09","conditions":"Nervous Restlessness","enrollment":154},{"nctId":"NCT03953469","phase":"NA","title":"Short-term Effects of Passiflora and Meditation on Blood Pressure and Heart Rate","status":"UNKNOWN","sponsor":"University of Bridgeport","startDate":"2020-08","conditions":"Heart Rate Fast, Blood Pressure","enrollment":250},{"nctId":"NCT00982787","phase":"PHASE2","title":"Safety and Anticonvulsant Efficacy of Passiflora Incarnata Extract in Patients With Partial Epilepsy","status":"WITHDRAWN","sponsor":"Oregon Health and Science University","startDate":"2009-09","conditions":"Partial Epilepsy","enrollment":""},{"nctId":"NCT03780595","phase":"PHASE4","title":"Passiflora Extract for Benzodiazepine Withdrawal","status":"UNKNOWN","sponsor":"Nutricion Medica S.L.","startDate":"2018-09-27","conditions":"Benzodiazepine Withdrawal (Disorder)","enrollment":108},{"nctId":"NCT02065843","phase":"PHASE2, PHASE3","title":"Three Anxiolytic Drugs Used in Third Molar Surgery","status":"COMPLETED","sponsor":"Universidade Federal de Sergipe","startDate":"2014-03","conditions":"Dental Anxiety, Impacted Third Molar Tooth","enrollment":30},{"nctId":"NCT01695616","phase":"PHASE3","title":"Efficacy and Safety of Passiflora Incarnata and Isoflavona Combination in the Treatment of Climacteric Symptoms","status":"WITHDRAWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2013-08","conditions":"Climacteric Syndrome","enrollment":""},{"nctId":"NCT01665170","phase":"PHASE3","title":"Pilot Study on the Efficacy of Pascoflair in an Acute Stressful Situation (TSST)","status":"COMPLETED","sponsor":"Pascoe Pharmazeutische Praeparate GmbH","startDate":"2012-05","conditions":"Healthy, Stress","enrollment":60},{"nctId":"NCT00794456","phase":"PHASE3","title":"Association of Passiflora Incarnata L; Crataegus Oxyacantha L and Salix Alba L. on Mild and Moderate Anxiety","status":"COMPLETED","sponsor":"Marjan Industria e Comercio ltda","startDate":"2009-09","conditions":"Anxiety Disorder","enrollment":150},{"nctId":"NCT01100645","phase":"PHASE3","title":"Efficacy and Safety of the Herbal Medicine Sominex ® (Passiflora Incarnata L., Valeriana Officinalis L. and Crataegus Oxyacantha L.), Manufactured by the Laboratory EMS S / A in Patients With Psychophysiological Insomnia","status":"UNKNOWN","sponsor":"Azidus Brasil","startDate":"2010-10","conditions":"Insomnia","enrollment":100},{"nctId":"NCT00944268","phase":"PHASE3","title":"Efficacy and Tolerability Study to Treat Mild and Moderate Anxiety","status":"UNKNOWN","sponsor":"Ativus Farmaceutica Ltda","startDate":"2009-09","conditions":"Anxiety, Efficacy, Tolerability","enrollment":124}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":190,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pascoflair 425mg coated tablets"],"phase":"marketed","status":"active","brandName":"Passiflora incarnata","genericName":"Passiflora incarnata","companyName":"Nutricion Medica S.L.","companyId":"nutricion-medica-s-l","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Passiflora incarnata contains alkaloids and flavonoids that modulate GABAergic and serotonergic neurotransmission to produce anxiolytic and sedative effects. Used for Anxiety and nervousness, Insomnia and sleep disorders, Restlessness.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}