{"id":"passiflora-crataegus-e-salix","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Passiflora (passionflower) acts as a mild anxiolytic and sedative through GABA receptor modulation. Crataegus (hawthorn) provides cardiotonic effects by improving cardiac contractility and coronary blood flow. Salix (willow bark) contributes anti-inflammatory and analgesic activity through salicylate compounds. Together, these botanicals are traditionally used to support cardiovascular function and emotional well-being.","oneSentence":"This herbal combination product works through the synergistic anxiolytic, cardiotonic, and anti-inflammatory properties of its three plant constituents to promote cardiovascular and nervous system health.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:25:50.150Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anxiety and nervous tension"},{"name":"Cardiovascular support and mild heart palpitations"}]},"trialDetails":[{"nctId":"NCT00944268","phase":"PHASE3","title":"Efficacy and Tolerability Study to Treat Mild and Moderate Anxiety","status":"UNKNOWN","sponsor":"Ativus Farmaceutica Ltda","startDate":"2009-09","conditions":"Anxiety, Efficacy, Tolerability","enrollment":124}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Passiflora, Crataegus e Salix","genericName":"Passiflora, Crataegus e Salix","companyName":"Ativus Farmaceutica Ltda","companyId":"ativus-farmaceutica-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Passiflora and the combination of Crataegus and Salix have been studied in clinical trials for their efficacy and tolerability in treating mild and moderate anxiety. The mechanism of action for these substances is currently unknown.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}