{"id":"passiflora-crataegus-and-salix","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Allergic reactions (rare)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Passiflora (passionflower) contains alkaloids and flavonoids that modulate GABAergic neurotransmission to reduce anxiety and promote relaxation. Crataegus (hawthorn) contains flavonoids and proanthocyanidins that support cardiac function and improve coronary blood flow. Salix (willow bark) provides salicin, which has anti-inflammatory and mild analgesic properties. Together, these botanicals are intended to support cardiovascular health and emotional well-being.","oneSentence":"This herbal combination product works by promoting cardiovascular relaxation and mild sedation through the synergistic effects of passionflower's anxiolytic properties, hawthorn's cardiotonic effects, and willow's anti-inflammatory action.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:25:50.051Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anxiety and nervous tension"},{"name":"Cardiovascular support and mild hypertension"}]},"trialDetails":[{"nctId":"NCT00794456","phase":"PHASE3","title":"Association of Passiflora Incarnata L; Crataegus Oxyacantha L and Salix Alba L. on Mild and Moderate Anxiety","status":"COMPLETED","sponsor":"Marjan Industria e Comercio ltda","startDate":"2009-09","conditions":"Anxiety Disorder","enrollment":150},{"nctId":"NCT00944268","phase":"PHASE3","title":"Efficacy and Tolerability Study to Treat Mild and Moderate Anxiety","status":"UNKNOWN","sponsor":"Ativus Farmaceutica Ltda","startDate":"2009-09","conditions":"Anxiety, Efficacy, Tolerability","enrollment":124}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pasalix"],"phase":"phase_3","status":"active","brandName":"Passiflora ; Crataegus and Salix","genericName":"Passiflora ; Crataegus and Salix","companyName":"Marjan Industria e Comercio ltda","companyId":"marjan-industria-e-comercio-ltda","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This herbal combination product works by promoting cardiovascular relaxation and mild sedation through the synergistic effects of passionflower's anxiolytic properties, hawthorn's cardiotonic effects, and willow's anti-inflammatory action. Used for Anxiety and nervous tension, Cardiovascular support and mild hypertension.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}