{"id":"paroxetine-aerobic-exercise","safety":{"commonSideEffects":[{"rate":"15-25","effect":"Nausea"},{"rate":"20-40","effect":"Sexual dysfunction"},{"rate":"10-20","effect":"Headache"},{"rate":"10-20","effect":"Insomnia or somnolence"},{"rate":null,"effect":"Muscle soreness (exercise-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that blocks serotonin reuptake at the synaptic cleft, increasing serotonergic neurotransmission. Aerobic exercise complements this by increasing brain-derived neurotrophic factor (BDNF), improving cardiovascular function, and promoting endogenous neurochemical changes that enhance antidepressant efficacy. The combination leverages both pharmacological and behavioral mechanisms to treat depression.","oneSentence":"Paroxetine increases serotonin availability in the brain while aerobic exercise enhances neuroplasticity and mood regulation through multiple physiological pathways.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:52.802Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Major depressive disorder"},{"name":"Generalized anxiety disorder"}]},"trialDetails":[{"nctId":"NCT07025590","phase":"NA","title":"Effect of Exercise on Tapering Antipsychotics in Patients With Psycho-cardiological Disease(EXTRA-study)","status":"RECRUITING","sponsor":"Guangdong Provincial People's Hospital","startDate":"2025-04-22","conditions":"Cardiovascular Diseases (CVD), Depression Anxiety Disorder","enrollment":106},{"nctId":"NCT02612142","phase":"NA","title":"Physical EXercise as an Adjunct Treatment for Depression","status":"COMPLETED","sponsor":"Université de Reims Champagne-Ardenne","startDate":"2011-06","conditions":"Major Depressive Disorder","enrollment":48},{"nctId":"NCT00540098","phase":"PHASE4","title":"Paroxetine vs Placebo Combined With Aerobic Exercise or Relaxation in Panic Disorder","status":"COMPLETED","sponsor":"University of Göttingen","startDate":"2001-09","conditions":"Panic Disorder","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"paroxetine + aerobic exercise","genericName":"paroxetine + aerobic exercise","companyName":"University of Göttingen","companyId":"university-of-g-ttingen","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paroxetine increases serotonin availability in the brain while aerobic exercise enhances neuroplasticity and mood regulation through multiple physiological pathways. Used for Major depressive disorder, Generalized anxiety disorder.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}