{"id":"paromomycin-sulfate-powder","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbances (nausea, diarrhea, abdominal discomfort)"},{"rate":null,"effect":"Ototoxicity (with systemic absorption)"},{"rate":null,"effect":"Nephrotoxicity (with systemic absorption)"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2206196","moleculeType":"Small molecule","molecularWeight":"713.71"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paromomycin sulfate is an aminoglycoside antibiotic that works by irreversibly binding to the bacterial 30S ribosomal subunit, disrupting protein synthesis and leading to bacterial cell death. It has broad-spectrum activity against gram-negative and gram-positive bacteria, as well as some activity against certain parasites. The drug is bactericidal and is commonly used for gastrointestinal infections and parasitic diseases.","oneSentence":"Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:55.789Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastrointestinal infections caused by susceptible gram-negative and gram-positive bacteria"},{"name":"Parasitic infections (e.g., amebiasis, cryptosporidiosis)"}]},"trialDetails":[{"nctId":"NCT03759886","phase":"","title":"Oral Antibiotic Prophylaxis in Colorectal Surgery","status":"UNKNOWN","sponsor":"University of Leipzig","startDate":"2018-12-17","conditions":"Surgical Site Infection, Anastomotic Leak","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Metronidazole"],"phase":"phase_3","status":"active","brandName":"Paromomycin Sulfate Powder","genericName":"Paromomycin Sulfate Powder","companyName":"University of Leipzig","companyId":"university-of-leipzig","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Used for Gastrointestinal infections caused by susceptible gram-negative and gram-positive bacteria, Parasitic infections (e.g., amebiasis, cryptosporidiosis).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}