{"id":"paromomycin-alone-topical-cream","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"}]},"_chembl":{"chemblId":"CHEMBL2108947","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paromomycin works by disrupting bacterial protein synthesis through irreversible binding to the bacterial 30S ribosomal subunit, leading to misreading of mRNA codons and ultimately cell death. As a topical cream formulation, it achieves high local concentrations at the site of infection while minimizing systemic absorption. This mechanism makes it effective against a range of gram-negative and gram-positive bacteria, as well as certain parasites.","oneSentence":"Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when applied topically as a cream, it kills or inhibits the growth of susceptible microorganisms on the skin surface.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:25:40.877Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cutaneous leishmaniasis (topical treatment)"}]},"trialDetails":[{"nctId":"NCT03829917","phase":"PHASE2, PHASE3","title":"Oral Miltefosine Plus Topical Paromomycin In American Cutaneous Leishmaniasis","status":"COMPLETED","sponsor":"Fundacion Nacional de Dermatologia","startDate":"2019-02-01","conditions":"Cutaneous Leishmaniasis, American","enrollment":120},{"nctId":"NCT01790659","phase":"PHASE3","title":"Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama","status":"COMPLETED","sponsor":"U.S. Army Medical Research and Development Command","startDate":"2013-05","conditions":"Cutaneous Leishmaniasis","enrollment":399},{"nctId":"NCT01032382","phase":"PHASE2","title":"Safety, Efficacy and Pharmacokinetics (PK) Study of WR 279,396 Versus Paromomycin for Treatment of Cutaneous Leishmaniasis (Peru-PK)","status":"COMPLETED","sponsor":"U.S. Army Medical Research and Development Command","startDate":"2010-01","conditions":"Leishmaniasis, Cutaneous","enrollment":30},{"nctId":"NCT01083576","phase":"PHASE2","title":"Pharmacokinetics, Safety, and Efficacy Trial of WR 279,396 (Paromomycin + Gentamicin Topical Cream) and Paromomycin Topical Cream for the Treatment of Cutaneous Leishmaniasis in Panama","status":"COMPLETED","sponsor":"U.S. Army Medical Research and Development Command","startDate":"2010-03","conditions":"Leishmaniasis, Cutaneous","enrollment":30},{"nctId":"NCT00606580","phase":"PHASE3","title":"Phase 3 Study to Evaluate WR 279,396 vs. Paromomycin Alone to Treat Cutaneous Leishmaniasis (in Tunisia)","status":"COMPLETED","sponsor":"U.S. Army Medical Research and Development Command","startDate":"2008-01","conditions":"Cutaneous Leishmaniasis","enrollment":375}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Paromomycin Alone topical cream","genericName":"Paromomycin Alone topical cream","companyName":"U.S. Army Medical Research and Development Command","companyId":"u-s-army-medical-research-and-development-command","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paromomycin is an aminoglycoside antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, and when applied topically as a cream, it kills or inhibits the growth of susceptible microorganisms on the skin surface. Used for Cutaneous leishmaniasis (topical treatment).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}