{"id":"parenteral-oral-methadone-ratio-1-1-2","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"20-30","effect":"Sedation"},{"rate":"10-20","effect":"Sweating"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"QT prolongation"},{"rate":"10-20","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL651","moleculeType":"Small molecule","molecularWeight":"309.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methadone acts as a full mu opioid receptor agonist with a long half-life, making it suitable for maintenance therapy in opioid use disorder and chronic pain management. The 1:1.2 parenteral-to-oral ratio indicates the relative potency difference between intravenous/intramuscular and oral administration routes, reflecting differences in bioavailability and first-pass metabolism.","oneSentence":"Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and suppress withdrawal symptoms.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:37.821Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Opioid use disorder maintenance treatment"},{"name":"Chronic pain management"},{"name":"Opioid withdrawal syndrome"}]},"trialDetails":[{"nctId":"NCT01836328","phase":"PHASE3","title":"Conversion From Parenteral to Oral Methadone.","status":"COMPLETED","sponsor":"L'Hospitalet de Llobregat","startDate":"2011-08","conditions":"Pain","enrollment":44}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Eptadone (1mg/ml) oral solution"],"phase":"phase_3","status":"active","brandName":"Parenteral /oral methadone ratio 1:1.2","genericName":"Parenteral /oral methadone ratio 1:1.2","companyName":"L'Hospitalet de Llobregat","companyId":"l-hospitalet-de-llobregat","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and suppress withdrawal symptoms. Used for Opioid use disorder maintenance treatment, Chronic pain management, Opioid withdrawal syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}