{"id":"parenteral-administration-of-analgesics","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Injection site reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Parenteral administration refers to delivery of analgesic drugs via routes other than oral (e.g., intravenous, intramuscular, subcutaneous), allowing rapid onset and precise dosing control. The specific mechanism depends on the analgesic class used—opioids bind mu receptors to reduce pain perception, NSAIDs inhibit prostaglandin synthesis, and other agents may modulate neurotransmitter reuptake or ion channels. This route is particularly useful for acute pain management in hospital settings where rapid analgesia is required.","oneSentence":"Parenteral analgesics work by blocking pain signal transmission through various mechanisms including opioid receptor agonism, norepinephrine/serotonin reuptake inhibition, or direct nociceptive pathway modulation when administered via injection or infusion routes.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:59:57.292Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain management in hospitalized patients"},{"name":"Postoperative pain"},{"name":"Severe pain requiring rapid onset analgesia"}]},"trialDetails":[{"nctId":"NCT07413055","phase":"PHASE3","title":"Dexamethasone (4 mg vs. 8 mg) for Pain Control in Dental Implant Surgery","status":"RECRUITING","sponsor":"Oman Ministry of Health","startDate":"2026-02-05","conditions":"Postoperative 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