{"id":"parecoxib-valdecoxib-parecoxib-and-dexamethasone","safety":{"commonSideEffects":[{"rate":null,"effect":"Cardiovascular events (myocardial infarction, stroke)"},{"rate":null,"effect":"Gastrointestinal ulceration"},{"rate":null,"effect":"Renal dysfunction"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Edema"}]},"_chembl":{"chemblId":"CHEMBL1206690","moleculeType":"Small molecule","molecularWeight":"370.43"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"These drugs selectively inhibit cyclooxygenase-2 (COX-2), an enzyme responsible for producing pro-inflammatory prostaglandins. By blocking COX-2 while sparing COX-1, they provide pain relief and reduce inflammation with potentially fewer gastrointestinal side effects than non-selective NSAIDs. When combined with dexamethasone (a corticosteroid), the anti-inflammatory effects are potentiated.","oneSentence":"Parecoxib and valdecoxib are selective COX-2 inhibitors that reduce prostaglandin synthesis to provide anti-inflammatory and analgesic effects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:51.079Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute postoperative pain"},{"name":"Rheumatoid arthritis"},{"name":"Osteoarthritis"}]},"trialDetails":[{"nctId":"NCT01361789","phase":"PHASE4","title":"COX-2 Inhibitor Versus Glucocorticoid Versus Both Combined","status":"COMPLETED","sponsor":"Asker & Baerum Hospital","startDate":"2004-01","conditions":"Rupture of Anterior Cruciate Ligament","enrollment":93}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"parecoxib, valdecoxib, parecoxib and dexamethasone","genericName":"parecoxib, valdecoxib, parecoxib and dexamethasone","companyName":"Asker & Baerum Hospital","companyId":"asker-baerum-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Parecoxib and valdecoxib are selective COX-2 inhibitors that reduce prostaglandin synthesis to provide anti-inflammatory and analgesic effects. Used for Acute postoperative pain, Rheumatoid arthritis, Osteoarthritis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}