{"id":"parathiazine","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Motion sickness","category":"indication"},{"label":"Vomiting of pregnancy","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pyrathiazine","offLabel":[],"synonyms":["pyrathiazine theoclate","pyrathiazine monohydrochloride","pyrathiazine HCl","pyrathiazine","parathiazine"],"timeline":[],"approvals":[],"brandName":"Pyrathiazine","ecosystem":[{"indication":"Motion sickness","otherDrugs":[{"name":"buclizine","slug":"buclizine","company":"Stuart Pharms"},{"name":"cyclizine","slug":"cyclizine","company":"Glaxosmithkline"},{"name":"dimenhydrinate","slug":"dimenhydrinate","company":"Alra"},{"name":"meclozine","slug":"meclozine","company":"Citron Pharma Llc"}],"globalPrevalence":null},{"indication":"Vomiting of pregnancy","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body has a 'nausea switch' that gets flipped when you're feeling queasy. Pyrathiazine is like a key that blocks this switch from being flipped, helping to prevent nausea and vomiting. This allows you to feel more comfortable and recover from illness.","oneSentence":"Pyrathiazine works by blocking the action of certain chemicals in the body that cause nausea and vomiting.","technicalDetail":"Pyrathiazine's exact mechanism of action is unknown, but it is believed to act as a histamine H1 receptor antagonist, which may contribute to its antiemetic effects."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/2327","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=parathiazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:14:01.284245","biosimilars":[],"competitors":[],"genericName":"parathiazine","indications":{"approved":[{"name":"Motion sickness","source":"DrugCentral","snomedId":37031009,"regulator":"FDA"},{"name":"Vomiting of pregnancy","source":"DrugCentral","snomedId":90325002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"2305SQ56Z2","CHEBI":"CHEBI:135253","INN_ID":"4164","UMLSCUI":"C0072654","ChEMBL_ID":"CHEMBL1887666","DRUGBANK_ID":"DB15978","PUBCHEM_CID":"10646","SNOMEDCT_US":"35864006","MESH_SUPPLEMENTAL_RECORD_UI":"C017691"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":5,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Pyrathiazine is a small molecule. It is also known by the synonyms PARATHIAZINE and PARATIAZINA.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}