{"id":"paragard-tcu380a","safety":{"commonSideEffects":[{"rate":null,"effect":"Increased menstrual bleeding"},{"rate":null,"effect":"Menstrual cramping"},{"rate":null,"effect":"Pelvic pain"},{"rate":"2-10","effect":"Device expulsion"},{"rate":"0.1-1","effect":"Uterine perforation"}]},"_chembl":{"chemblId":"CHEMBL55643","moleculeType":"Small molecule","molecularWeight":"63.55"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The device releases copper ions that are toxic to sperm, impairing their motility and fertilization capacity. Additionally, the copper and inflammatory response triggered by the device alter the endometrial environment, making implantation of a fertilized egg unlikely. This multi-mechanism approach provides long-acting reversible contraception without systemic hormonal effects.","oneSentence":"ParaGard TCu380A is a copper-releasing intrauterine device that prevents pregnancy through copper ion toxicity to sperm and alteration of the uterine environment.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:34.312Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Contraception in women of reproductive age"}]},"trialDetails":[{"nctId":"NCT03124160","phase":"PHASE3","title":"Compare Two Copper IUDs: Mona Lisa NT Cu380 Mini and ParaGard","status":"COMPLETED","sponsor":"FHI 360","startDate":"2017-05-26","conditions":"Healthy Women, Female Contraception","enrollment":1105}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":103,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["T380"],"phase":"phase_3","status":"active","brandName":"ParaGard® TCu380A","genericName":"ParaGard® TCu380A","companyName":"FHI 360","companyId":"fhi-360","modality":"Small molecule","firstApprovalDate":"","aiSummary":"ParaGard TCu380A is a copper-releasing intrauterine device that prevents pregnancy through copper ion toxicity to sperm and alteration of the uterine environment. Used for Contraception in women of reproductive age.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}