{"id":"paracetamol-ondansetron","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Nausea"},{"rate":"5-10%","effect":"Vomiting"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Paracetamol's mechanism of action is thought to involve the inhibition of prostaglandin synthesis through the inhibition of cyclooxygenase enzymes, which are involved in the production of prostaglandins. This reduction in prostaglandin synthesis leads to a decrease in pain and fever. Ondansetron, on the other hand, acts as a selective serotonin 5-HT3 receptor antagonist, which prevents the action of serotonin on the 5-HT3 receptors in the central nervous system, thereby reducing nausea and vomiting.","oneSentence":"Paracetamol acts as a non-selective inhibitor of cyclooxygenase enzymes, reducing prostaglandin synthesis and thereby decreasing pain and fever. Ondansetron acts as a selective serotonin 5-HT3 receptor antagonist, inhibiting the action of serotonin and reducing nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:40.690Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Treatment of pain and fever"},{"name":"Prevention of nausea and vomiting caused by chemotherapy, radiation therapy, and surgery"}]},"trialDetails":[{"nctId":"NCT07458282","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Transversus Abdominis Plane Block","enrollment":318},{"nctId":"NCT07458295","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Gynecologic Oncology Patient, Liposomal Bupivacaine","enrollment":110},{"nctId":"NCT07458256","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-10","conditions":"Laparoscopic Surgery, Liposomal Bupivacaine, Local Infiltration","enrollment":190},{"nctId":"NCT06869967","phase":"NA","title":"Evaluation of Postoperative Pain Control in Ear Surgery","status":"RECRUITING","sponsor":"Kocaeli University","startDate":"2025-10-20","conditions":"Post Operative Pain, Analgesia","enrollment":56},{"nctId":"NCT06862609","phase":"NA","title":"QIPB in Inguinal Hernia","status":"RECRUITING","sponsor":"Konya City Hospital","startDate":"2025-03-23","conditions":"Postoperative Pain","enrollment":70},{"nctId":"NCT02858310","phase":"PHASE1, PHASE2","title":"E7 TCR T Cells for Human Papillomavirus-Associated Cancers","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2017-01-27","conditions":"Papillomavirus Infections, Cervical Intraepithelial Neoplasia, Carcinoma In Situ","enrollment":224},{"nctId":"NCT07432711","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":100},{"nctId":"NCT07442539","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Hemorrhoid Surgery, Liposome Bupivacaine, Pain Management","enrollment":156},{"nctId":"NCT07441902","phase":"NA","title":"The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery","status":"RECRUITING","sponsor":"Beijing Tiantan Hospital","startDate":"2026-03-02","conditions":"Video-assisted Thoracoscopic Surgery (VATS), Pain Management, Liposomal Bupivacaine","enrollment":134},{"nctId":"NCT06324253","phase":"NA","title":"Thoracic Epidural Analgesia With Bilateral Erector Spinae Plane Block in Radical Cystectomy Surgery","status":"COMPLETED","sponsor":"Menoufia University","startDate":"2024-03-30","conditions":"Post Operative Pain","enrollment":20},{"nctId":"NCT04743661","phase":"PHASE2","title":"131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Pediatric Brain Tumor Consortium","startDate":"2022-04-04","conditions":"Recurrent Medulloblastoma, Recurrent Ependymoma","enrollment":62},{"nctId":"NCT06707818","phase":"","title":"Psychosocial Factors and Postoperative Pain in Aesthetic Breast Surgery","status":"COMPLETED","sponsor":"V.K.V. 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