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The combination is commonly used to improve efficacy in pain management.","oneSentence":"Paracetamol reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system, while caffeine enhances analgesic efficacy and increases alertness.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:25:40.731Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain relief"},{"name":"Fever reduction"}]},"_fixedFields":["pubmed(1)"],"trialDetails":[{"nctId":"NCT05055830","phase":"","title":"Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)","status":"RECRUITING","sponsor":"Duke University","startDate":"2021-10-05","conditions":"Cardiac Disease, Critically Ill, Children, Adult","enrollment":2000},{"nctId":"NCT07022496","phase":"PHASE4","title":"Assessment of Oral Caffeine Intake in Changing the Severity of Acute Migraine Attack Using VAS Score Among Patients Attending Headache and Neurology Outpatients Clinic 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Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain.","status":"UNKNOWN","sponsor":"Ache Laboratorios Farmaceuticos S.A.","startDate":"2021-01","conditions":"Postural Low Back Pain, Mechanical Low Back Pain","enrollment":110},{"nctId":"NCT04259333","phase":"PHASE4","title":"Celecoxib vs. Acetaminophen/Codeine/Caffeine for Post-operative Analgesia in Rhinoplasty.","status":"UNKNOWN","sponsor":"Blake Raggio","startDate":"2020-03-01","conditions":"Pain, Postoperative, Surgery--Complications, Opioid Analgesic Adverse Reaction","enrollment":60},{"nctId":"NCT01629329","phase":"PHASE4","title":"Prochlorperazine Versus Acetaminophen, Aspirin, and Caffeine for the Treatment of Acute Migraine","status":"TERMINATED","sponsor":"Albert Einstein Healthcare Network","startDate":"2010-11","conditions":"Migraine 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