{"id":"paracetamol-500-mg-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Hepatotoxicity (at overdose)"},{"rate":"0.5–1","effect":"Rash"},{"rate":"1–2","effect":"Nausea"},{"rate":"1–2","effect":"Abdominal pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Paracetamol (acetaminophen) works primarily by inhibiting cyclooxygenase (COX) enzymes in the brain and spinal cord, reducing prostaglandin production and thereby lowering pain perception and body temperature set point. Unlike NSAIDs, it has minimal peripheral anti-inflammatory effects and does not significantly inhibit COX in peripheral tissues, making it gentler on the gastrointestinal tract and cardiovascular system.","oneSentence":"Paracetamol inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:38.196Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild to moderate pain"},{"name":"Fever reduction"}]},"trialDetails":[{"nctId":"NCT07154433","phase":"NA","title":"A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery","status":"RECRUITING","sponsor":"Second Affiliated Hospital, School of Medicine, Zhejiang University","startDate":"2025-09-01","conditions":"Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect","enrollment":110},{"nctId":"NCT05051735","phase":"PHASE3","title":"PARASTOP - Paracetamol With Strong Opioids","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2021-10-20","conditions":"Cancer Pain, Cancer","enrollment":204},{"nctId":"NCT05548582","phase":"NA","title":"Reduced Opioid Prescription After Laparoscopic Hysterectomy","status":"ACTIVE_NOT_RECRUITING","sponsor":"Johns Hopkins University","startDate":"2023-01-12","conditions":"Pain, Postoperative, Opioid Misuse, Opioid Use","enrollment":120},{"nctId":"NCT05469204","phase":"PHASE4","title":"Effect of Estrogen Treatment on Drug Metabolism and Transport","status":"COMPLETED","sponsor":"University of Washington","startDate":"2022-11-01","conditions":"Transgender Persons","enrollment":22},{"nctId":"NCT06434233","phase":"PHASE4","title":"Opioid Use After Laparoscopic Salpingectomy","status":"RECRUITING","sponsor":"Johns Hopkins University","startDate":"2024-04-25","conditions":"Opioid Use, Post-operative Pain, Sterility, Female","enrollment":120},{"nctId":"NCT06874959","phase":"NA","title":"Evaluation of the Pain Relief Effect of Battlefield Acupuncture on Patients With Chronic Low Back Pain Due to Lumbar Spine Degeneration.","status":"COMPLETED","sponsor":"University of Medicine and Pharmacy at Ho Chi Minh City","startDate":"2025-03-15","conditions":"Spondylosis Lumbar","enrollment":60},{"nctId":"NCT06861920","phase":"PHASE4","title":"NSAID Use for Treating Dysmenorrhea and Preventing Chronic Pelvic Pain (NSAID HEAL)","status":"RECRUITING","sponsor":"Endeavor Health","startDate":"2025-04-07","conditions":"Dysmenorrhea, Chronic Pelvic Pain, Pelvic Pain","enrollment":600},{"nctId":"NCT04532931","phase":"PHASE2","title":"Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19","status":"COMPLETED","sponsor":"Shin Poong Pharmaceutical Co. Ltd.","startDate":"2020-09-03","conditions":"COVID-19","enrollment":192},{"nctId":"NCT05540470","phase":"NA","title":"Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield","status":"COMPLETED","sponsor":"Centre Hospitalier de Cayenne","startDate":"2022-09-12","conditions":"Malaria, Vivax","enrollment":1991},{"nctId":"NCT05076110","phase":"PHASE4","title":"Nonopioid Pain Control Regimen After Arthroscopic Hip Procedures","status":"RECRUITING","sponsor":"Mayo Clinic","startDate":"2022-04-07","conditions":"Hip Arthroscopy","enrollment":188},{"nctId":"NCT05965492","phase":"PHASE3","title":"Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery","status":"WITHDRAWN","sponsor":"University of Miami","startDate":"2024-06-01","conditions":"Spinal Disorder","enrollment":""},{"nctId":"NCT06855576","phase":"PHASE1","title":"Bioequivalence Study of Paracetamol With Oral Single Dose Administration in Healthy Adult Subjects Under Fasting Conditions","status":"COMPLETED","sponsor":"HALEON","startDate":"2025-03-05","conditions":"Fever, Pain","enrollment":54},{"nctId":"NCT06917118","phase":"NA","title":"Multimodal Pain Management After Wide Awake Local Anesthesia No Tourniquet Orthopedic Hand Surgery: A Randomized Control Trial","status":"NOT_YET_RECRUITING","sponsor":"University of Puerto Rico","startDate":"2025-05-01","conditions":"Pain Management","enrollment":100},{"nctId":"NCT06863636","phase":"PHASE3","title":"Efficacy and Safety of Celecoxib/Acetaminophen Versus Celecoxib for Diagnosed Osteoarthritis in Acute Exacerbation","status":"RECRUITING","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2024-09-09","conditions":"Joint Pain, Knee Osteoarthritis, Hip Osteoarthritis","enrollment":231},{"nctId":"NCT06517264","phase":"NA","title":"Effectiveness and Safety of Outpatient Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics","status":"ENROLLING_BY_INVITATION","sponsor":"Monica Mengual Ballester","startDate":"2024-11-01","conditions":"Diverticulitis, Colonic","enrollment":282},{"nctId":"NCT04972292","phase":"PHASE3","title":"Fixed Dose Combination of COdeine + DIpyrone to Mitigate Moderate to Intense Pain Post-impacted Third Lower Molar Extraction","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2023-11-08","conditions":"Pain","enrollment":288},{"nctId":"NCT05081102","phase":"PHASE3","title":"Fixed-dose Combination of Oxycodone [OXIcodona] + IbuproFEN in Pain Relief After Third Molar Extraction","status":"COMPLETED","sponsor":"Eurofarma Laboratorios S.A.","startDate":"2024-03-27","conditions":"Pain","enrollment":288},{"nctId":"NCT03475693","phase":"EARLY_PHASE1","title":"A Cohort Study Evaluating the Efficacy of PO Magnesium in the Treatment of Acute Traumatic Brain Injury in Adolescents","status":"COMPLETED","sponsor":"Corewell Health South","startDate":"2017-09-01","conditions":"Concussion Post Syndrome","enrollment":17},{"nctId":"NCT04622735","phase":"PHASE3","title":"Nefopam/Paracetamol Fixed Dose Combination in Acute Pain After Impacted Third Molar Extraction","status":"COMPLETED","sponsor":"Unither Pharmaceuticals, France","startDate":"2020-02-22","conditions":"Acute Pain","enrollment":321},{"nctId":"NCT05463367","phase":"PHASE2","title":"Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure","status":"ACTIVE_NOT_RECRUITING","sponsor":"Northwestern University","startDate":"2021-01-01","conditions":"Opioid Use, Opioid Dependence, Opioid-use Disorder","enrollment":60},{"nctId":"NCT04323566","phase":"PHASE2","title":"Rituximab Treatment for Psychosis And/or Obsessive Compulsive Disorder with Probable Immune System Involvement","status":"ENROLLING_BY_INVITATION","sponsor":"Uppsala University Hospital","startDate":"2022-05-01","conditions":"Obsessive-Compulsive Disorder, Obsessive-Compulsive Behavior, Schizophrenia","enrollment":40},{"nctId":"NCT05129137","phase":"PHASE1","title":"Pharmacokinetic Study of a Fixed Dose Combination Nefopam Hydrochloride (30 mg) / Paracetamol (500 mg)","status":"COMPLETED","sponsor":"Unither Pharmaceuticals, France","startDate":"2021-11-29","conditions":"Healthy Volunteers","enrollment":32},{"nctId":"NCT06420388","phase":"NA","title":"2% Lidocaine Gel in Reducing Postoperative Pain Following Haemorrhoidectomy","status":"RECRUITING","sponsor":"E-DA Hospital","startDate":"2023-05-01","conditions":"Surgery, Pain, Postoperative","enrollment":400},{"nctId":"NCT04580121","phase":"PHASE1","title":"A Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7283420.","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2020-11-04","conditions":"Acute Myeloid Leukemia","enrollment":59},{"nctId":"NCT04727424","phase":"PHASE3","title":"Repurposed Approved and Under Development Therapies for Patients With Early-Onset COVID-19 and Mild Symptoms","status":"RECRUITING","sponsor":"Cardresearch","startDate":"2021-01-19","conditions":"Covid19, SARS-Associated Coronavirus","enrollment":7819},{"nctId":"NCT05783206","phase":"PHASE2, PHASE3","title":"Evaluation of Safety & Efficacy of MIR 19 ® Inhalation Solution in Patients With Mild COVID-19","status":"COMPLETED","sponsor":"National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia","startDate":"2022-02-10","conditions":"COVID-19","enrollment":984},{"nctId":"NCT06111573","phase":"PHASE4","title":"Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial Pain","status":"COMPLETED","sponsor":"Yuzuncu Yil University","startDate":"2022-06-01","conditions":"Myofascial Pain Dysfunction Syndrome,Temporomandibular Joint","enrollment":40},{"nctId":"NCT04285853","phase":"PHASE4","title":"Are Opioids Needed After ACL Reconstruction","status":"COMPLETED","sponsor":"Emory University","startDate":"2020-09-16","conditions":"Anterior Cruciate Ligament Rupture","enrollment":98},{"nctId":"NCT03451487","phase":"NA","title":"A Randomized, Single-blind, Parallel Group and Multiple - Dose Design Study","status":"COMPLETED","sponsor":"Sinew Pharma Inc.","startDate":"2022-05-19","conditions":"Acetaminophen Toxicity","enrollment":28},{"nctId":"NCT05803681","phase":"NA","title":"CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial","status":"COMPLETED","sponsor":"University of Bari Aldo Moro","startDate":"2015-01-01","conditions":"Vertebral Fracture, Osteoporotic Fractures","enrollment":70},{"nctId":"NCT01086540","phase":"PHASE2","title":"Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2011-06-24","conditions":"Systemic Sclerosis-Associated PAH","enrollment":57},{"nctId":"NCT05222724","phase":"PHASE4","title":"Efficacy of the Combination of Ibuprofen and Paracetamol in Acute Non-specific Low Back Pain","status":"COMPLETED","sponsor":"Aziende Chimiche Riunite Angelini Francesco S.p.A","startDate":"2021-12-01","conditions":"Low Back Pain","enrollment":176},{"nctId":"NCT04920838","phase":"PHASE2, PHASE3","title":"Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection","status":"UNKNOWN","sponsor":"ANRS, Emerging Infectious Diseases","startDate":"2021-04-12","conditions":"Covid19, Covid19 Drug Treatment, Severe Acute Respiratory Syndrome Coronavirus 2","enrollment":600},{"nctId":"NCT03879408","phase":"PHASE2","title":"Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2019-05-28","conditions":"Pain","enrollment":290},{"nctId":"NCT04640376","phase":"PHASE3","title":"Paracetamol UNIFLASH for Buccal Use Phase III Trial in Acute Pain Due to a Tooth Extraction","status":"COMPLETED","sponsor":"Unither Pharmaceuticals, France","startDate":"2021-03-24","conditions":"Acute Pain","enrollment":407},{"nctId":"NCT02735122","phase":"PHASE3","title":"Study of Acetaminophen (ACM) in Post-operative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2016-04-30","conditions":"Post Operative Dental Pain","enrollment":420},{"nctId":"NCT05428306","phase":"PHASE1","title":"Pharmacokinetic Interaction Between Ibuprofen and Acetaminophen, Tablets Administered Individually or in Combination","status":"COMPLETED","sponsor":"Laboratorios Silanes S.A. de C.V.","startDate":"2018-10-23","conditions":"Healthy","enrollment":42},{"nctId":"NCT05417997","phase":"PHASE3","title":"Effect of Kunamin in SARS-CoV-2 RT-PCR Positive Covid-19 Patients","status":"COMPLETED","sponsor":"RAAS Nutritionals, LLC","startDate":"2021-05-29","conditions":"COVID-19 Respiratory Infection, FLU, Cold; Influenza","enrollment":71},{"nctId":"NCT02251249","phase":"PHASE4","title":"Impairment of Gastric Emptying During Acute Phase of Myocardial Infarction. Impact on Oral Antiplatelet Treatment Efficacy. The GASTRIM Study.","status":"COMPLETED","sponsor":"University Hospital, Bordeaux","startDate":"2014-12-08","conditions":"Impairment of Gastric Emptying, Acute Phase of Myocardial Infarction","enrollment":23},{"nctId":"NCT05161221","phase":"PHASE3","title":"Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-12-06","conditions":"Pain, Postoperative, ACL","enrollment":154},{"nctId":"NCT05154682","phase":"PHASE3","title":"Pain Management After Surgery","status":"UNKNOWN","sponsor":"Rothman Institute Orthopaedics","startDate":"2021-11-30","conditions":"Pain, Postoperative","enrollment":200},{"nctId":"NCT02320708","phase":"PHASE2","title":"Study of Acetaminophen (ACE) in Post-operative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Healthcare Products Division of McNEIL-PPC, Inc.","startDate":"2014-12-31","conditions":"Dental Pain","enrollment":240},{"nctId":"NCT03586934","phase":"PHASE3","title":"Multimodal Analgesia in Shoulder Arthroplasty","status":"WITHDRAWN","sponsor":"Rush University Medical Center","startDate":"2018-06-01","conditions":"Shoulder Pain, Opioid Use","enrollment":""},{"nctId":"NCT04673214","phase":"PHASE3","title":"Evaluation of Prognostic Modification in COVID-19 Patients in Early Intervention Treatment","status":"COMPLETED","sponsor":"Gilberto Cruz Arteaga","startDate":"2020-12-16","conditions":"Covid19","enrollment":114},{"nctId":"NCT04948164","phase":"PHASE3","title":"Study of Sumatriptan Naproxen Sodium Succinate Tablets for the Treatment of Acute Migraine Attacks","status":"UNKNOWN","sponsor":"Peking University Third Hospital","startDate":"2018-08-01","conditions":"Migraine in Adults","enrollment":240},{"nctId":"NCT03846102","phase":"PHASE4","title":"MORphine Use in the Fascia Iliaca Compartment Block With UltraSound","status":"TERMINATED","sponsor":"Zuyderland Medisch Centrum","startDate":"2019-01-28","conditions":"Humans, Anesthetics, Local, Morphine","enrollment":55},{"nctId":"NCT03224403","phase":"PHASE3","title":"Randomized, Double-Blind, Single-Dose, Efficacy and Safety Study of Test Acetaminophen Tablet in Postoperative Dental Pain","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division","startDate":"2017-07-19","conditions":"Post-operative Dental Pain","enrollment":664},{"nctId":"NCT03375593","phase":"PHASE4","title":"Narcotic Versus Non-narcotic Medication for Pain Management After Wrist/Hand Fractures","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2019-08-01","conditions":"Distal Radius Fracture, Pain Management, Metacarpal Fracture","enrollment":250},{"nctId":"NCT04769557","phase":"PHASE4","title":"Pre Emptive Analgesics for Pain Relief in Impacted Lower Third Molar Surgery","status":"COMPLETED","sponsor":"Melaka Manipal Medical College","startDate":"2017-03-04","conditions":"Impacted Third Molar Tooth","enrollment":60},{"nctId":"NCT04730297","phase":"PHASE4","title":"Comparative Analgesic Effects of Paracetamol/Codeine and Ibuprofen on Pain After Third Molar Surgery","status":"COMPLETED","sponsor":"University of Roma La Sapienza","startDate":"2018-01-01","conditions":"To Control Pain After Third Molar Surgery","enrollment":120},{"nctId":"NCT04483596","phase":"","title":"Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-07-30","conditions":"Postoperative Delirium","enrollment":100},{"nctId":"NCT04523740","phase":"NA","title":"Paracetamol Discontinuation in the Elderly After Long-term Consumption","status":"UNKNOWN","sponsor":"University Hospital Bispebjerg and Frederiksberg","startDate":"2020-08","conditions":"Pain, Chronic, Pain, Medication, Pain, Discontinuation","enrollment":98},{"nctId":"NCT02848729","phase":"PHASE4","title":"Drug Interactions Between Morphine and Orally or IV Administered Acetaminophen","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2016-02","conditions":"Pain","enrollment":50},{"nctId":"NCT04202224","phase":"NA","title":"Pre-emptive Analgesia Effect in Different Psycho-emotional Status Patients During Lower Third Molar Surgical Extractions","status":"COMPLETED","sponsor":"Lithuanian University of Health Sciences","startDate":"2018-10-01","conditions":"Pre-emptive Analgesia in Different Psycho-emotional Status Patients","enrollment":45},{"nctId":"NCT04200885","phase":"PHASE4","title":"Is Therapeutic Elastic Bandage As Effective As Corticosteroids Following Third Molar Surgery?","status":"COMPLETED","sponsor":"Tokat Gaziosmanpasa University","startDate":"2019-05-02","conditions":"Third Molar Surgery","enrollment":52},{"nctId":"NCT02746263","phase":"PHASE4","title":"Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain","status":"TERMINATED","sponsor":"Mallinckrodt","startDate":"2016-04-27","conditions":"Acute Pain, Postoperative","enrollment":1},{"nctId":"NCT03910088","phase":"PHASE4","title":"Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean","status":"COMPLETED","sponsor":"Cairo University","startDate":"2019-04-20","conditions":"Post-Dural Puncture Headache","enrollment":30},{"nctId":"NCT03448536","phase":"PHASE4","title":"A Study to Assess Menstrual Cramp Pain Associated With Primary Dysmenorrhea","status":"COMPLETED","sponsor":"Bayer","startDate":"2018-04-05","conditions":"Dysmenorrhea","enrollment":201},{"nctId":"NCT02241148","phase":"NA","title":"Close Kinetic Chain Exercise With Kinesio Taping in the Management of Patellofemoral Pain Syndrome","status":"TERMINATED","sponsor":"Universidad Autonoma de Nuevo Leon","startDate":"2014-02","conditions":"Patellofemoral Pain Syndrome","enrollment":15},{"nctId":"NCT03400111","phase":"NA","title":"The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment","status":"COMPLETED","sponsor":"Damascus University","startDate":"2017-09-15","conditions":"Pain and Discomfort, Orthodontic Appliance Complication","enrollment":60},{"nctId":"NCT03953287","phase":"PHASE1","title":"Pharmacokinetic Study of Paracetamol.","status":"UNKNOWN","sponsor":"Kolding Sygehus","startDate":"2019-08-18","conditions":"Pharmacological Action","enrollment":12},{"nctId":"NCT02833584","phase":"NA","title":"Safety of Paracetamol as Antipyretic in Treatment of Dengue Infection in Adults","status":"COMPLETED","sponsor":"Phramongkutklao College of Medicine and Hospital","startDate":"2016-09","conditions":"Dengue, Transaminitis","enrollment":123},{"nctId":"NCT01420094","phase":"PHASE3","title":"Evaluate Onset of Action of a Fast Release Aspirin","status":"COMPLETED","sponsor":"Bayer","startDate":"2011-06-16","conditions":"Healthy Subjects","enrollment":510},{"nctId":"NCT01552798","phase":"PHASE3","title":"Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache","status":"TERMINATED","sponsor":"Bayer","startDate":"2012-03-12","conditions":"Headache","enrollment":9},{"nctId":"NCT03686293","phase":"NA","title":"A Personal Microbiome-dependent Glucose Response in Healthy Young Volunteers","status":"COMPLETED","sponsor":"University of Copenhagen","startDate":"2018-10-12","conditions":"Blood Glucose, High","enrollment":31},{"nctId":"NCT02761980","phase":"PHASE3","title":"A Study of Ibuprofen 250 mg / Acetaminophen 500 mg Comparing The Antipyretic Effects in Healthy Male Volunteers","status":"COMPLETED","sponsor":"Pfizer","startDate":"2016-12-06","conditions":"Fever","enrollment":290},{"nctId":"NCT01453400","phase":"PHASE3","title":"Evaluate the Time of Pain Relief of Fast Acting Aspirin Versus Acetaminophen in Subjects Diagnosed With Sore Throat Pain","status":"COMPLETED","sponsor":"Bayer","startDate":"2011-09-27","conditions":"Pharyngitis","enrollment":177},{"nctId":"NCT03568721","phase":"PHASE4","title":"Postoperative Effects of Chewing Gum, Ibuprofen and Acetaminophen on Pain After Initial Archwire Placement","status":"COMPLETED","sponsor":"Rio de Janeiro State University","startDate":"2015-01-25","conditions":"Pain","enrollment":81},{"nctId":"NCT00758836","phase":"PHASE2","title":"A Study to Test the Safety and Effectiveness of MK-0974 (Telcagepant) Co-administered With Ibuprofen or Acetaminophen in Patients With Migraines With or Without Aura (MK-0974-046)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2008-12-03","conditions":"Migraine","enrollment":683},{"nctId":"NCT00662818","phase":"PHASE3","title":"Telcagepant (MK-0974) Treatment of Migraine in Participants With Stable Vascular Disease (MK-0974-034)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2008-03-17","conditions":"Migraine Disorders, Heart Disease, Cerebrovascular Accident","enrollment":165},{"nctId":"NCT01229449","phase":"PHASE3","title":"Ibuprofen/Acetaminophen Versus Nurofen Plus® and Panadeine® Extra Dental Pain Study","status":"COMPLETED","sponsor":"Reckitt Benckiser LLC","startDate":"2009-01","conditions":"Post-operative Pain","enrollment":678},{"nctId":"NCT02974114","phase":"PHASE4","title":"Exploratory Study to Investigate Cognition Function and Mobility in Individuals With Pain","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2016-10-31","conditions":"Pain","enrollment":21},{"nctId":"NCT03058224","phase":"NA","title":"Efficacy and Safety of IGN-ES001 in Chronic Widespread Pain With or Without Fibromyalgia","status":"COMPLETED","sponsor":"IgNova GmbH","startDate":"2017-02-16","conditions":"Chronic Widespread Pain, Fibromyalgia","enrollment":230},{"nctId":"NCT02504775","phase":"NA","title":"Bioequivalence Study for Mejoral 500 Product","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-08-01","conditions":"Pain","enrollment":28},{"nctId":"NCT03122561","phase":"NA","title":"Estimation of Paracetamol in Urine to Assess the Diurnal Variation","status":"COMPLETED","sponsor":"Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh","startDate":"2016-11-03","conditions":"Diurnal Variation of Paracetamol Excretion","enrollment":46},{"nctId":"NCT03213353","phase":"PHASE1","title":"A Bioequivalence Study Between Two Brands of Medications to Treat Cough & Cold Symptoms","status":"COMPLETED","sponsor":"Johnson & Johnson Consumer and Personal Products Worldwide","startDate":"2017-07-03","conditions":"Bioequivalence, Healthy Volunteers","enrollment":72},{"nctId":"NCT02074709","phase":"PHASE4","title":"TAP Block With Plain Bupivacaine Versus Wound Infiltration With Exparel for Postoperative Pain Management","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2014-01","conditions":"Postoperative Pain","enrollment":60},{"nctId":"NCT03518463","phase":"NA","title":"Enhanced Recovery After Surgery for Emergency Caesarean Deliveries","status":"COMPLETED","sponsor":"Mbarara University of Science and Technology","startDate":"2017-06-20","conditions":"Pregnancy Related","enrollment":160},{"nctId":"NCT02837952","phase":"PHASE3","title":"A Study of Ibuprofen (IBU) 250mg/APAP 500mg In The Treatment Of Post-Surgical Dental Pain","status":"COMPLETED","sponsor":"Pfizer","startDate":"2016-08-31","conditions":"Pain","enrollment":123},{"nctId":"NCT01153503","phase":"NA","title":"Ultrasound-guided Transversus Abdominis Plane Block After Hysterectomy","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2010-04","conditions":"Post Operative Pain","enrollment":75},{"nctId":"NCT03243006","phase":"NA","title":"Effect of Early Pain Management at Triage on Opioid Consumption","status":"COMPLETED","sponsor":"University of Monastir","startDate":"2016-01-01","conditions":"Acute Pain","enrollment":1500},{"nctId":"NCT02180334","phase":"PHASE4","title":"The Effect of Combination of Mosapride and DPP-4 Inhibitor on Plasma Concentration of Incretin Hormones","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2014-07","conditions":"Diabetes Mellitus, Type 2","enrollment":12},{"nctId":"NCT01708473","phase":"NA","title":"Feasibility Study: Compare the Effectiveness Between Two Pain Medications When Used Prior to Ultherapy™ Treatments","status":"COMPLETED","sponsor":"Ulthera, Inc","startDate":"2011-07","conditions":"Skin Laxity","enrollment":20},{"nctId":"NCT00411190","phase":"PHASE1","title":"Study To Determine The Effects Of Doses Of Relacatib On The Metabolism Of Acetaminophen, Ibuprofen And Atorvastatin","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-10-19","conditions":"Osteoarthritis","enrollment":32},{"nctId":"NCT01842633","phase":"PHASE3","title":"Clinical Study to Evaluate Efficacy of New Paracetamol Formulation Compared to Ibuprofen in Headache","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2013-04-01","conditions":"Pain","enrollment":365},{"nctId":"NCT02912650","phase":"PHASE3","title":"A Safety And Efficacy Study of Ibuprofen 250 mg / Acetaminophen 500 mg In The Treatment Of Post-Surgical Dental Pain","status":"COMPLETED","sponsor":"Pfizer","startDate":"2015-09","conditions":"Post-surgical Pain Following Extraction of Molar Teeth","enrollment":568},{"nctId":"NCT00346151","phase":"PHASE2","title":"Belatacept to Prevent Organ Rejection in Kidney Transplant Patients","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2006-12","conditions":"Renal Transplant","enrollment":5},{"nctId":"NCT02032927","phase":"PHASE4","title":"Treatment of Chronic Pain From Osteoarthritis","status":"WITHDRAWN","sponsor":"Fondazione IRCCS Policlinico San Matteo di Pavia","startDate":"2013-06","conditions":"Chronic Pain","enrollment":""},{"nctId":"NCT01448057","phase":"PHASE3","title":"Evaluation of Efficacy and Safety of Tablets of Paracetamol, Dimethindene Maleate and Phenylephrine Hydrochloride in Reducing Symptoms of Common Cold and Flu","status":"COMPLETED","sponsor":"Novartis","startDate":"2013-07","conditions":"Upper Respiratory Tract Infection, Nasal Congestion, Rhinorrhea","enrollment":341},{"nctId":"NCT02902666","phase":"PHASE1","title":"Bioequivalence Study of One Tablet of Paracetamol 1000 mg + Codeine 30 mg vs. Two Tablets of Paracetamol 500 mg + Codeine 30 mg","status":"COMPLETED","sponsor":"Aziende Chimiche Riunite Angelini Francesco S.p.A","startDate":"2016-04","conditions":"Healthy","enrollment":46},{"nctId":"NCT00377364","phase":"PHASE4","title":"Acetaminophen (Tylenol) for Mood and Memory Changes Associated With Corticosteroid Therapy","status":"COMPLETED","sponsor":"University of Texas Southwestern Medical Center","startDate":"2006-11","conditions":"Asthma, Rheumatic Disease","enrollment":30},{"nctId":"NCT02750696","phase":"NA","title":"Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess","status":"COMPLETED","sponsor":"Federal University of Rio Grande do Sul","startDate":"2013-04","conditions":"Periapical Abscess","enrollment":27},{"nctId":"NCT02262702","phase":"","title":"Panadol Osteo Pharmaceuticals Benefit Scheme (PBS) Claims Cohort Study","status":"WITHDRAWN","sponsor":"GlaxoSmithKline","startDate":"2013-01","conditions":"Osteoarthritis","enrollment":""},{"nctId":"NCT00772967","phase":"PHASE1","title":"A Study to Evaluate the Effect of Analgesics on a Walking Model of Knee Pain (0000-105)(COMPLETED)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2008-06","conditions":"Osteoarthritis","enrollment":22},{"nctId":"NCT01938144","phase":"PHASE3","title":"Evaluation of the Efficacy and Safety of Two Ibuprofen Combination Products for the Treatment of the Common Cold and Flu in Latin America","status":"WITHDRAWN","sponsor":"Pfizer","startDate":"2016-04","conditions":"Common Cold","enrollment":""},{"nctId":"NCT02307591","phase":"PHASE2, PHASE3","title":"Clinical Study to Assess Efficacy and Safety of Amiodarone in Treating Patients With Ebola. Virus Disease (EVD) in Sierra Leone. EASE (EMERGENCY Amiodarone Study Against Ebola)","status":"WITHDRAWN","sponsor":"Emergency NGO Onlus","startDate":"2014-12","conditions":"Ebola Virus Disease","enrollment":""},{"nctId":"NCT01332578","phase":"PHASE4","title":"A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2011-05","conditions":"Influenza, Common Cold","enrollment":25},{"nctId":"NCT01958866","phase":"PHASE2, PHASE3","title":"Study of Efficacy and Safety of Tinospora Crispa-extract Product Compared With the Acetaminophen","status":"COMPLETED","sponsor":"Chulalongkorn University","startDate":"2013-10","conditions":"Patients With Body Temperature Between 37.8-38.5, No Sign of Infection, No Liver and Kidney Problem","enrollment":96},{"nctId":"NCT01465009","phase":"PHASE4","title":"Placebo and Active Controlled Study to Compare the Efficacy of Aspirin and Paracetamol in Treatment of Sore Throat Associated With a Common Cold","status":"COMPLETED","sponsor":"Bayer","startDate":"2003-11","conditions":"Common Cold, Pharyngitis, Tonsillitis","enrollment":508},{"nctId":"NCT01822665","phase":"PHASE4","title":"Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2012-02","conditions":"Gastrointestinal Mucosal Damage","enrollment":28}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ACIDOSIS"},{"count":1,"reaction":"COAGULOPATHY"},{"count":1,"reaction":"CONSTIPATION"},{"count":1,"reaction":"CONVULSION"},{"count":1,"reaction":"HYPERGLYCAEMIA"},{"count":1,"reaction":"INTENTIONAL DOSE OMISSION"},{"count":1,"reaction":"INTENTIONAL OVERDOSE"},{"count":1,"reaction":"KETOSIS"},{"count":1,"reaction":"LIVER FUNCTION TEST ABNORMAL"},{"count":1,"reaction":"METHAEMOGLOBINAEMIA"}],"_approvalHistory":[],"publicationCount":12,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Paracetamol (500 mg) tablets","genericName":"Paracetamol (500 mg) tablets","companyName":"Novartis","companyId":"novartis","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paracetamol inhibits prostaglandin synthesis in the central nervous system to reduce pain and fever. Used for Mild to moderate pain, Fever reduction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}