{"id":"panvac-vf","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Fatigue"},{"rate":null,"effect":"Myalgia"}]},"_chembl":{"chemblId":"CHEMBL2268786","moleculeType":"Small molecule","molecularWeight":"480.56"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PANVAC-VF combines a vaccinia virus vector expressing ras and CEA antigens with a fowlpox virus booster to generate cellular and humoral immune responses against tumor cells. The vaccine is designed to activate T cells and other immune effectors to target cancers that express these common tumor-associated antigens, particularly in colorectal and other gastrointestinal malignancies.","oneSentence":"PANVAC-VF is a therapeutic cancer vaccine that stimulates the immune system to recognize and attack cancer cells expressing ras and CEA tumor-associated antigens.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:25:28.538Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Metastatic colorectal cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[{"nctId":"NCT00088660","phase":"PHASE3","title":"PANVAC™-VF Vaccine for the Treatment of Metastatic Pancreatic Cancer After Failing a Gemcitabine-Containing Regimen","status":"UNKNOWN","sponsor":"Therion Biologics Corporation","startDate":"2004-06","conditions":"Pancreatic Cancer","enrollment":250}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"PANVAC™-VF","genericName":"PANVAC™-VF","companyName":"Therion Biologics Corporation","companyId":"therion-biologics-corporation","modality":"Biologic","firstApprovalDate":"","aiSummary":"PANVAC-VF is a therapeutic cancer vaccine that stimulates the immune system to recognize and attack cancer cells expressing ras and CEA tumor-associated antigens. Used for Metastatic colorectal cancer, Pancreatic cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}