{"id":"pantoprazole-pantoloc","safety":{"commonSideEffects":[{"rate":"12-15%","effect":"Headache"},{"rate":"8-12%","effect":"Diarrhea"},{"rate":"5-8%","effect":"Nausea"},{"rate":"4-6%","effect":"Abdominal pain"},{"rate":"3-5%","effect":"Constipation"},{"rate":"1-2%","effect":"Hypomagnesemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pantoprazole is a proton pump inhibitor (PPI) that irreversibly binds to and inactivates the H+/K+-ATPase enzyme on the secretory surface of gastric parietal cells. This blocks the final step of gastric acid production, significantly reducing both basal and stimulated acid secretion. It is used to treat acid-related gastrointestinal disorders by maintaining elevated gastric pH.","oneSentence":"Pantoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:50:57.035Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Peptic ulcer disease"},{"name":"Zollinger-Ellison syndrome"},{"name":"Acid-related gastrointestinal disorders"}]},"trialDetails":[{"nctId":"NCT06564246","phase":"PHASE4","title":"Clinical Study Evaluating The Role of Vonoprazan Versus Pantoprazole in Patients With Gastroesophageal Reflux Disease","status":"RECRUITING","sponsor":"Tanta University","startDate":"2024-09-18","conditions":"Gastroesophageal Reflux Disease (GERD)","enrollment":44},{"nctId":"NCT06710600","phase":"NA","title":"Phototoxicity of Frequently Prescribed Medicines","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2022-09-22","conditions":"Phototoxicity","enrollment":12},{"nctId":"NCT03908593","phase":"PHASE4","title":"Proton Pump Inhibitor Preventing Upper Gastrointestinal Injury In Patients On Dual Antiplatelet Therapy After CABG","status":"UNKNOWN","sponsor":"Ruijin Hospital","startDate":"2019-10-14","conditions":"Gastrointestinal Ulcer (Peptic) or Erosion, Anti-Platelet Therapy, Coronary Artery Bypass","enrollment":232},{"nctId":"NCT02467621","phase":"PHASE4","title":"Stress Ulcer Prophylaxis in the Intensive Care Unit","status":"COMPLETED","sponsor":"Dr. Morten Hylander Møller","startDate":"2016-01","conditions":"Gastrointestinal Bleeding, Stress Ulcers","enrollment":3350},{"nctId":"NCT02197039","phase":"","title":"The Selection Criteria for the Second-look Endoscopy Among Patients With Bleeding Peptic Ulcers","status":"COMPLETED","sponsor":"National Cheng-Kung University Hospital","startDate":"2011-08","conditions":"Peptic Ulcer Hemorrhage","enrollment":316},{"nctId":"NCT02213887","phase":"PHASE4","title":"Study of the Effects of Pantoprazole on Levels of Prescribed Psychiatric Medications","status":"WITHDRAWN","sponsor":"University of British Columbia","startDate":"2014-09","conditions":"Psychotic Disorders, Gastroesophageal Reflux","enrollment":""},{"nctId":"NCT04366583","phase":"PHASE4","title":"Argon Plasma Coagulation vs Hemoclipping for Bleeding Peptic Ulcers","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2012-02-09","conditions":"Bleeding Peptic Ulcer","enrollment":166},{"nctId":"NCT03038009","phase":"PHASE4","title":"Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft","status":"WITHDRAWN","sponsor":"Ruijin Hospital","startDate":"2018-10","conditions":"Gastric Ulcer Induced by Antiplatelet Agent, Ulcer of the Gastrointestinal Tract, Proton Pump Inhibitor","enrollment":""},{"nctId":"NCT02466919","phase":"PHASE4","title":"Study of Levofloxacin-based Concomitant Therapy for H. 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Co., Ltd.","startDate":"2012-12","conditions":"Peptic Ulcer","enrollment":323},{"nctId":"NCT00681005","phase":"NA","title":"A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes","status":"COMPLETED","sponsor":"National Taiwan University Hospital","startDate":"2006-04","conditions":"GERD","enrollment":178},{"nctId":"NCT00839488","phase":"PHASE4","title":"Comparison of Intravenous Pantoprazole and Famotidine for Stress Ulcer Prophylaxis","status":"TERMINATED","sponsor":"Far Eastern Memorial Hospital","startDate":"2008-04","conditions":"Stomach Ulcer","enrollment":6},{"nctId":"NCT01857609","phase":"PHASE1","title":"Clinical Trial to Investigate the Effect of Proton Pump Inhibitor on the Pharmacokinetics and Pharmacodynamics of Metformin","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2012-08","conditions":"Healthy","enrollment":24},{"nctId":"NCT01821521","phase":"PHASE1","title":"Investigate a Pharmacokinetics Between S-pantoprazole 20mg and Pantoprazole 40mg in Healthy Male Subjects","status":"UNKNOWN","sponsor":"Ahn-Gook Pharmaceuticals Co.,Ltd","startDate":"2013-06","conditions":"Healthy Male Subjects","enrollment":44},{"nctId":"NCT01182597","phase":"PHASE3","title":"Oral Versus IV Proton Pump Inhibitor in High-risk Bleeding Peptic Ulcers After Endoscopic Hemostasis","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2010-08","conditions":"Peptic Ulcers","enrollment":190},{"nctId":"NCT01146483","phase":"PHASE1","title":"Drug-drug Interaction Study in Healthy Male Volunteers Following the Administration of Pantoprazole and Rosuvastatin","status":"COMPLETED","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2010-04","conditions":"Drug Interaction Potentiation","enrollment":16},{"nctId":"NCT01400945","phase":"PHASE3","title":"Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease","status":"COMPLETED","sponsor":"Ahn-Gook Pharmaceuticals Co.,Ltd","startDate":"2009-12","conditions":"Gastroesophageal Reflux Disease","enrollment":154},{"nctId":"NCT00709046","phase":"NA","title":"High Dose Versus Standard Dose Proton Pump Inhibitor (PPI) in High-risk Bleeding Peptic Ulcers After Combined Endoscopic Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2008-01","conditions":"Endoscopy, Peptic Ulcer, Bleeding","enrollment":150},{"nctId":"NCT00731601","phase":"PHASE4","title":"Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding","status":"COMPLETED","sponsor":"Lotung Poh-Ai Hospital","startDate":"2008-05","conditions":"Peptic Ulcer Hemorrhage","enrollment":120},{"nctId":"NCT00843063","phase":"PHASE4","title":"Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion","status":"COMPLETED","sponsor":"Ruttonjee Hospital","startDate":"2004-08","conditions":"Peptic Ulcer/Erosions","enrollment":161}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pantoprazole (Pantoloc)","genericName":"Pantoprazole (Pantoloc)","companyName":"National Taiwan University Hospital","companyId":"national-taiwan-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pantoprazole inhibits the proton pump in gastric parietal cells, reducing gastric acid secretion. Used for Gastroesophageal reflux disease (GERD), Peptic ulcer disease, Zollinger-Ellison syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}