{"id":"pantoprazole-bolus","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Hypomagnesemia (with chronic use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pantoprazole binds to and inactivates the proton pump (H+/K+-ATPase) on the secretory surface of gastric parietal cells, preventing the final step of gastric acid production. This reduces intragastric pH and acid-related damage to the gastrointestinal mucosa. The bolus formulation provides rapid intravenous delivery for acute acid suppression in clinical settings.","oneSentence":"Pantoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:35:40.684Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute gastric acid suppression in hospitalized patients"},{"name":"Peptic ulcer disease"},{"name":"Gastroesophageal reflux disease (GERD)"},{"name":"Stress ulcer prophylaxis"}]},"trialDetails":[{"nctId":"NCT06062719","phase":"PHASE2, PHASE3","title":"Role of Octreotide in Non Variceal Bleeding","status":"UNKNOWN","sponsor":"National Hepatology & Tropical Medicine Research Institute","startDate":"2023-08-23","conditions":"Non-variceal Gastrointestinal Bleeding","enrollment":56},{"nctId":"NCT03814421","phase":"NA","title":"Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding","status":"UNKNOWN","sponsor":"Samsung Changwon Hospital","startDate":"2016-04-15","conditions":"Peptic Ulcer Hemorrhage, Peptic Ulcer, Acute With Hemorrhage, Peptic Ulcer","enrollment":200},{"nctId":"NCT02757703","phase":"PHASE4","title":"Vasoactive Drugs in Real World Practice","status":"COMPLETED","sponsor":"Kaohsiung Veterans General Hospital.","startDate":"2010-05","conditions":"Vasoconstrictor Choice on Acute Variceal Bleeding","enrollment":150},{"nctId":"NCT02502877","phase":"NA","title":"Core Temperature Variations During Midazolam vs Propofol Sedation for Neuraxial Anesthesia","status":"COMPLETED","sponsor":"Hospital da Luz, Portugal","startDate":"2015-07","conditions":"Body Temperature Changes, Anesthesia","enrollment":27},{"nctId":"NCT00881413","phase":"PHASE4","title":"Esomeprazole Versus Pantoprazole to Prevent Peptic Ulcer Rebleeding","status":"WITHDRAWN","sponsor":"Lotung Poh-Ai Hospital","startDate":"","conditions":"Peptic Ulcer","enrollment":""},{"nctId":"NCT00709046","phase":"NA","title":"High Dose Versus Standard Dose Proton Pump Inhibitor (PPI) in High-risk Bleeding Peptic Ulcers After Combined Endoscopic Treatment","status":"UNKNOWN","sponsor":"National Taiwan University Hospital","startDate":"2008-01","conditions":"Endoscopy, Peptic Ulcer, Bleeding","enrollment":150},{"nctId":"NCT00279123","phase":"PHASE4","title":"Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers","status":"COMPLETED","sponsor":"Kwong Wah Hospital","startDate":"2002-01","conditions":"Peptic Ulcer Hemorrhage","enrollment":""}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"PNEUMONIA"},{"count":1,"reaction":"SEPSIS"},{"count":1,"reaction":"SEPTIC SHOCK"}],"_approvalHistory":[],"publicationCount":50,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"pantoprazole bolus","genericName":"pantoprazole bolus","companyName":"Kwong Wah Hospital","companyId":"kwong-wah-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Pantoprazole is a proton pump inhibitor that suppresses gastric acid secretion by irreversibly blocking the H+/K+-ATPase enzyme in gastric parietal cells. Used for Acute gastric acid suppression in hospitalized patients, Peptic ulcer disease, Gastroesophageal reflux disease (GERD).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}