{"id":"pantoprazole-40mg-amoxicillin-and-levofloxacin","safety":{"commonSideEffects":[{"rate":"10-15","effect":"Diarrhea"},{"rate":"5-10","effect":"Nausea"},{"rate":"5-8","effect":"Headache"},{"rate":"3-7","effect":"Abdominal pain"},{"rate":"2-5","effect":"Rash"},{"rate":"1-2","effect":"Tendinopathy (levofloxacin-related)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Pantoprazole is a proton pump inhibitor that blocks gastric acid secretion by inhibiting the H+/K+-ATPase pump in parietal cells. Amoxicillin and levofloxacin are broad-spectrum antibiotics that work synergistically to eradicate Helicobacter pylori and other pathogenic bacteria. Together, this combination addresses both the acid-related damage and the underlying bacterial infection.","oneSentence":"This is a triple-therapy combination that suppresses gastric acid while simultaneously targeting bacterial pathogens associated with peptic ulcer disease and gastritis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:36.280Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helicobacter pylori eradication in peptic ulcer disease"},{"name":"Gastritis associated with H. pylori infection"}]},"trialDetails":[{"nctId":"NCT06414707","phase":"PHASE3","title":"Efficacy of Vonoprazan in Eradication of Resistant Strain of Helicobacter Pylori","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2023-10-12","conditions":"Helicobacter Pylori Infection","enrollment":320},{"nctId":"NCT04660123","phase":"PHASE4","title":"A Real World Study of Bismuth Colloidal Pectin Granules Quadruple Therapy for H. Pylori Eradication","status":"COMPLETED","sponsor":"Xijing Hospital of Digestive Diseases","startDate":"2020-12-20","conditions":"Gastric Cancer, Helicobacter Pylori Infection, Bismuth","enrollment":959},{"nctId":"NCT04107194","phase":"PHASE3","title":"Non-invasive Test-guided Tailored Therapy Versus Empiric Treatment for Helicobacter Pylori Infection.","status":"UNKNOWN","sponsor":"University of Bari","startDate":"2020-01-14","conditions":"Helicobacter Pylori Infection, Antibiotic Resistant Infection, Antibiotic Resistant Strain","enrollment":362},{"nctId":"NCT04352062","phase":"NA","title":"Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia","status":"COMPLETED","sponsor":"Medical University of Lodz","startDate":"2011-01-09","conditions":"Melatonin Deficiency","enrollment":152}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["controloc 40 mg","Amoxil 1 gm","Tavanic 500 mg"],"phase":"phase_3","status":"active","brandName":"Pantoprazole 40mg, Amoxicillin and Levofloxacin","genericName":"Pantoprazole 40mg, Amoxicillin and Levofloxacin","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a triple-therapy combination that suppresses gastric acid while simultaneously targeting bacterial pathogens associated with peptic ulcer disease and gastritis. Used for Helicobacter pylori eradication in peptic ulcer disease, Gastritis associated with H. pylori infection.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}