{"id":"pangramin-slit-hdm-mix","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Local mouth edema"},{"rate":null,"effect":"Gastrointestinal symptoms"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This sublingual immunotherapy (SLIT) product contains a standardized mixture of house dust mite (HDM) allergen extracts designed to induce immune tolerance. By administering small amounts of allergen under the tongue, the treatment promotes a shift from Th2-mediated allergic responses toward Th1/Treg-mediated tolerance, reducing allergic symptoms and airway hyperresponsiveness over time.","oneSentence":"Pangramin SLIT HDM mix is a sublingual immunotherapy that desensitizes the immune system to house dust mite allergens through repeated exposure to gradually increasing doses.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:56.005Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or asthma induced by house dust mite allergens"}]},"trialDetails":[{"nctId":"NCT01603056","phase":"PHASE3","title":"Efficacy and Safety Trial of Pangramin SLIT HDM-mix in Subjects With House Dust Mite Induced Rhinitis","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2009-10","conditions":"Allergic Rhinitis","enrollment":617}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Pangramin SLIT HDM mix.","genericName":"Pangramin SLIT HDM mix.","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Biologic","firstApprovalDate":"","aiSummary":"Pangramin SLIT HDM mix is a sublingual immunotherapy that desensitizes the immune system to house dust mite allergens through repeated exposure to gradually increasing doses. Used for Allergic rhinitis and/or asthma induced by house dust mite allergens.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}