{"id":"pancreozymin","rwe":[],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Cholecystokinin receptor type A","category":"target"},{"label":"CCKAR","category":"gene"},{"label":"CCKBR","category":"gene"},{"label":"V04CK02","category":"atc"},{"label":"Active","category":"status"},{"label":"Pancreatic function test","category":"indication"},{"label":"Cholagogues and Choleretics","category":"pharmacology"},{"label":"Gastrointestinal Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"pankreozymin","offLabel":[],"synonyms":["pancreozymin","cholecystokinin","CCK","pankreozymin","CCK-PZ","uropancreozymin","cholecystokinin 33","CCK-33"],"timeline":[],"approvals":[],"brandName":"Pankreozymin","ecosystem":[{"indication":"Pancreatic function test","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"Cholecystokinin receptor type A","targets":[{"gene":"CCKAR","source":"DrugCentral","target":"Cholecystokinin receptor type A","protein":"Cholecystokinin receptor type A"},{"gene":"CCKBR","source":"DrugCentral","target":"Gastrin/cholecystokinin type B receptor","protein":"Gastrin/cholecystokinin type B receptor"}],"modality":"Small Molecule","explanation":"Imagine your pancreas as a factory that produces digestive enzymes. Cholecystokinin is a hormone that tells the pancreas to release these enzymes into the small intestine to help break down food. Pankreozymin is a synthetic version of this hormone that triggers the same response, allowing doctors to test how well the pancreas is functioning.","oneSentence":"Pankreozymin works by binding to the cholecystokinin receptor type A, mimicking the natural hormone cholecystokinin.","technicalDetail":"Pankreozymin acts as a cholecystokinin receptor type A agonist, stimulating the release of pancreatic enzymes and bile through the contraction of the gallbladder and pancreas."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4945","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=pancreozymin","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=pancreozymin","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:15:04.043383","biosimilars":[],"competitors":[{"drugName":"secretin human","drugSlug":"secretin-human","fdaApproval":"2002-04-04","relationship":"same-class"},{"drugName":"bentiromide","drugSlug":"bentiromide","fdaApproval":"1983-12-29","patentStatus":"Unknown","relationship":"same-class"}],"genericName":"pancreozymin","indications":{"approved":[{"name":"Pancreatic function test","source":"DrugCentral","snomedId":252243002,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"secretin-human","brandName":"secretin human","genericName":"secretin human","approvalYear":"2002","relationship":"same-class"},{"drugId":"bentiromide","brandName":"bentiromide","genericName":"bentiromide","approvalYear":"1983","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07138716","phase":"NA","title":"Research on the Application of 68Ga-DOTA-CCK-FS PET/CT in MTC","status":"RECRUITING","sponsor":"Luo Yaping","startDate":"2025-05-10","conditions":["Medullary Thyroid Carcinoma"],"enrollment":30,"completionDate":"2028-12-01"},{"nctId":"NCT07019519","phase":"NA","title":"POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS","status":"RECRUITING","sponsor":"University of Copenhagen","startDate":"2025-03-15","conditions":["Postural Orthostatic 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Copenhagen","startDate":"2020-12-10","conditions":["Gallbladder"],"enrollment":15,"completionDate":"2021-04-27"},{"nctId":"NCT02809235","phase":"NA","title":"Fatty Acids in Airway Smooth Muscle of Asthmatics","status":"WITHDRAWN","sponsor":"Brigham and Women's Hospital","startDate":"2026-11","conditions":["Asthma"],"enrollment":0,"completionDate":"2029-11"},{"nctId":"NCT05774119","phase":"NA","title":"Effect of Coffee Consumption on Appetite Traits in Overweight and Obesity","status":"COMPLETED","sponsor":"University of Guadalajara","startDate":"2022-01-31","conditions":["Obesity"],"enrollment":10,"completionDate":"2023-09-01"},{"nctId":"NCT05551858","phase":"PHASE1,PHASE2","title":"Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis","status":"ACTIVE_NOT_RECRUITING","sponsor":"Georgetown University","startDate":"2022-11-17","conditions":["Safety Issues","Pain","Pancreas 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Houston","startDate":"2016-05-03","conditions":["Abdominal Pain"],"enrollment":50,"completionDate":"2018-06-14"},{"nctId":"NCT02496221","phase":"PHASE4","title":"A Study Evaluating the Effect of Albiglutide on Gallbladder Emptying in Healthy Subjects","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2015-06-11","conditions":["Diabetes Mellitus, Type 2"],"enrollment":20,"completionDate":"2015-10-13"},{"nctId":"NCT03331783","phase":"NA","title":"Assessment of the Effect of Output on New Adhesives","status":"COMPLETED","sponsor":"Coloplast A/S","startDate":"2017-09-27","conditions":["Ileostomy - Stoma"],"enrollment":5,"completionDate":"2017-10-17"},{"nctId":"NCT03289013","phase":"NA","title":"Assessement of the Peal Force Needed to Peel New Adhesives From the Skin","status":"COMPLETED","sponsor":"Coloplast A/S","startDate":"2017-09-11","conditions":["Ileostomy - Stoma"],"enrollment":5,"completionDate":"2017-12-21"},{"nctId":"NCT02497313","phase":"NA","title":"Effect of Metformin and Cholecystokinin-mediated Gallbladder Emptying on GLP-1 Secretion in Type 2 Diabetes","status":"COMPLETED","sponsor":"University Hospital, Gentofte, Copenhagen","startDate":"2015-07","conditions":["Diabetes Mellitus, Type 2"],"enrollment":15,"completionDate":"2016-07"},{"nctId":"NCT02445508","phase":"NA","title":"Effect of Bile Acid Secretion and Sequestration on GLP-1 Secretion","status":"COMPLETED","sponsor":"University Hospital, Gentofte, Copenhagen","startDate":"2015-05","conditions":["Diabetes Mellitus, Type 2"],"enrollment":15,"completionDate":"2016-07"},{"nctId":"NCT00651053","phase":"NA","title":"Endoscopic Ultrasound Compared With Pancreatic Function Testing for Diagnosis of Chronic Pancreatitis","status":"COMPLETED","sponsor":"The Cleveland Clinic","startDate":"2005-05","conditions":["Chronic Pancreatitis"],"enrollment":70,"completionDate":"2007-12"},{"nctId":"NCT01656057","phase":"NA","title":"The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion","status":"COMPLETED","sponsor":"Filip Krag Knop","startDate":"2012-07","conditions":["To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion"],"enrollment":10,"completionDate":"2014-04"},{"nctId":"NCT00004414","phase":"NA","title":"Sincalide (Cholecystokinin Octapeptide) Versus Placebo in Neonates at High Risk for Developing Parenteral Nutrition Associated Cholestasis","status":"COMPLETED","sponsor":"University of Michigan","startDate":"1997-09","conditions":["Cholestasis"],"enrollment":252,"completionDate":"2002-06"},{"nctId":"NCT01334840","phase":"NA","title":"Mechanism of Action of Vichy Catalan Water","status":"COMPLETED","sponsor":"National Research Council, Spain","startDate":"2009-11","conditions":["Cardiovascular Diseases"],"enrollment":21,"completionDate":"2010-07"},{"nctId":"NCT01008371","phase":"","title":"Investigation of Neuro-hormonal Mechanisms of Hunger, Fullness and Obesity.","status":"WITHDRAWN","sponsor":"Medical University of South Carolina","startDate":"2009-10","conditions":["Obesity","Gastric Emptying","Anxiety","Depression","Panic Disorder"],"enrollment":0,"completionDate":"2013-03"},{"nctId":"NCT00308776","phase":"NA","title":"Cholecystokinin for Reducing Binge Eating in People With Bulimia Nervosa","status":"TERMINATED","sponsor":"New York State Psychiatric Institute","startDate":"2003-10","conditions":["Bulimia Nervosa","Eating Disorders"],"enrollment":6,"completionDate":"2008-10"},{"nctId":"NCT00307190","phase":"","title":"Hormone Release and Stomach Disturbances in People With Binge Eating Disorder","status":"COMPLETED","sponsor":"New York State Psychiatric Institute","startDate":"2004-10","conditions":["Binge Eating Disorder","Obesity","Eating Disorders"],"enrollment":24,"completionDate":"2009-10"},{"nctId":"NCT00303264","phase":"PHASE2","title":"The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia.","status":"COMPLETED","sponsor":"Forest Laboratories","startDate":"2006-05","conditions":["Dyspepsia"],"enrollment":48,"completionDate":"2007-08"},{"nctId":"NCT01538784","phase":"PHASE1","title":"Safety, Tolerability and Pharmacokinetics of Single Rising Doses of YF476, a Gastrin Antagonist, in Healthy Men","status":"COMPLETED","sponsor":"Trio Medicines Ltd.","startDate":"1996-05","conditions":["Reflux Oesophagitis"],"enrollment":15,"completionDate":"1996-06"},{"nctId":"NCT01413126","phase":"NA","title":"Peanuts Second Meal Glycemic Response","status":"COMPLETED","sponsor":"Federal University of Vicosa","startDate":"2009-10","conditions":["Type 2 Diabetes Mellitus"],"enrollment":15,"completionDate":"2011-02"},{"nctId":"NCT00259532","phase":"NA","title":"Three New Methods for Diagnosing Pancreas Cancer","status":"UNKNOWN","sponsor":"University of Copenhagen","startDate":"2005-02","conditions":["Pancreas Cancer"],"enrollment":80,"completionDate":"2009-01"},{"nctId":"NCT00220090","phase":"PHASE3","title":"DARWIN Study: A Randomization/Withdrawal Efficacy Study of Dexloxiglumide in Constipation-Predominant Irritable Bowel Syndrome (C-IBS)","status":"COMPLETED","sponsor":"Rottapharm","startDate":"2003-07","conditions":["Irritable Bowel Syndrome"],"enrollment":0,"completionDate":""}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000007750","NDDF":"001219","CHEBI":"CHEBI:80345","RXNORM":"2420","UMLSCUI":"C0008328","ChEMBL_ID":"CHEMBL1121","DRUGBANK_ID":"DB08862","PUBCHEM_CID":"16129670","SNOMEDCT_US":"25085002","IUPHAR_LIGAND_ID":"3550","MESH_DESCRIPTOR_UI":"D002766"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Gastroenterology"],"atcClassification":{"source":"DrugCentral","atcCode":"V04CK02","allCodes":["V04CK02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Pankreozymin (pancreozymin) is a small molecule that targets the cholecystokinin receptor type A. It is used for pancreatic function tests, but its commercial status and pharmacokinetic properties are unknown. As a pancreatic function test agent, it is not intended for therapeutic use. The safety considerations of Pankreozymin are unclear due to a lack of available information. Further research is needed to fully understand its effects and potential risks.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}