{"id":"palonosetron-group-p","safety":{"commonSideEffects":[{"rate":"5–9","effect":"Headache"},{"rate":"3–5","effect":"Constipation"},{"rate":"2–4","effect":"Diarrhea"},{"rate":"1–3","effect":"Dizziness"},{"rate":"1–2","effect":"Fatigue"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Palonosetron binds with high affinity and selectivity to 5-hydroxytryptamine type 3 (5-HT3) receptors, which are located on vagal afferents in the gastrointestinal tract and in the chemoreceptor trigger zone of the brain. By antagonizing these receptors, it prevents the emetic signal cascade triggered by chemotherapy, radiation, or post-operative conditions. It has a longer half-life and greater receptor binding affinity compared to earlier-generation 5-HT3 antagonists.","oneSentence":"Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:35.928Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chemotherapy-induced nausea and vomiting (CINV) prevention"},{"name":"Post-operative nausea and vomiting (PONV) prevention"}]},"trialDetails":[{"nctId":"NCT06540885","phase":"PHASE4","title":"A Comparison Between Palonosetron Versus Granisetron as PONV Prophylaxis in Scoliotic Patients Undergoing Spine Surgery","status":"RECRUITING","sponsor":"University of Malaya","startDate":"2025-01-06","conditions":"Postoperative Nausea and Vomiting, Scoliosis","enrollment":74},{"nctId":"NCT04576390","phase":"PHASE4","title":"Palonosetron Versus Ondansetron for PONV Prevention in Patients Undergoing ERCP","status":"UNKNOWN","sponsor":"Theodor Bilharz Research Institute","startDate":"2020-10-24","conditions":"Antiemetic, Postoperative Nausea and Vomiting","enrollment":90},{"nctId":"NCT04060771","phase":"PHASE3","title":"Post-Operative Nausea and Vomiting in Children Submitted to Strabismus Surgery","status":"UNKNOWN","sponsor":"Universidade Federal Fluminense","startDate":"2018-08-01","conditions":"Anesthesia, Strabismus, PONV","enrollment":80},{"nctId":"NCT02744508","phase":"NA","title":"Comparison of Palonosetron Versus Combination of Palonosetron and Dexamethasone for Preventing Postoperative Vomiting in Patients Receiving Fentanyl by Patient-controlled Analgesia After Minor Orthopedic Surgery","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2015-07-24","conditions":"Orthopedic Surgery","enrollment":202},{"nctId":"NCT01478165","phase":"NA","title":"Comparison of TIVA (Total Intravenous Anesthesia) and TIVA Plus Palonosetron in Preventing Postoperative Nausea and Vomiting","status":"COMPLETED","sponsor":"Incheon St.Mary's Hospital","startDate":"2011-09","conditions":"Postoperative Nausea and Vomiting","enrollment":100}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["antiemetic"],"phase":"marketed","status":"active","brandName":"Palonosetron (Group P)","genericName":"Palonosetron (Group P)","companyName":"University of Malaya","companyId":"university-of-malaya","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Palonosetron is a highly selective 5-HT3 receptor antagonist that blocks serotonin signaling in the chemoreceptor trigger zone and gastrointestinal tract to prevent nausea and vomiting. Used for Chemotherapy-induced nausea and vomiting (CINV) prevention, Post-operative nausea and vomiting (PONV) prevention.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}