{"id":"paclical","safety":{"commonSideEffects":[{"rate":"High (> 40%)","effect":"Neutropenia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Paclitaxel works by binding to tubulin and stabilizing microtubules, preventing their disassembly and thereby inhibiting cell division. This leads to cell cycle arrest and ultimately apoptosis in rapidly dividing cancer cells. The formulation of paclitaxel in Paclical is designed to improve its solubility and delivery to cancer cells.","oneSentence":"Paclical is a formulation of paclitaxel, a microtubule inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:25:24.872Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Non-small cell lung cancer"},{"name":"Ovarian cancer"}]},"trialDetails":[{"nctId":"NCT00989131","phase":"PHASE3","title":"Study of Paclitaxel in Patients With Ovarian Cancer","status":"COMPLETED","sponsor":"Oasmia Pharmaceutical AB","startDate":"2009-02","conditions":"Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer","enrollment":789}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Paclical®","genericName":"Paclical®","companyName":"Oasmia Pharmaceutical AB","companyId":"oasmia-pharmaceutical-ab","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Paclical is a formulation of paclitaxel, a microtubule inhibitor that disrupts microtubule dynamics, leading to cell cycle arrest and apoptosis in cancer cells. Used for Non-small cell lung cancer, Ovarian cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}