{"id":"p53-with-chemotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Injection site reactions"},{"rate":null,"effect":"Chemotherapy-related toxicities (enhanced)"},{"rate":null,"effect":"Flu-like symptoms"}]},"_chembl":{"chemblId":"CHEMBL3347606","moleculeType":"Small molecule","molecularWeight":"2109.47"},"_fixedAt":"2026-03-30T18:40:36.523243","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This is a recombinant adenovirus-mediated p53 gene therapy (Gendicine) that transfects tumor cells with wild-type p53, restoring the tumor suppressor function lost in many cancers. When combined with chemotherapy, it enhances chemosensitivity by enabling p53-dependent apoptosis and DNA damage response in p53-mutant or p53-deficient tumors. The combination approach aims to improve treatment efficacy and overcome chemotherapy resistance.","oneSentence":"A gene therapy that delivers functional p53 tumor suppressor gene to cancer cells to restore apoptosis and cell cycle arrest, used in combination with chemotherapy.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:29.598Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head and neck squamous cell carcinoma (in combination with chemotherapy)"},{"name":"Various solid tumors with p53 deficiency or mutation (in combination with chemotherapy)"}]},"_fixedFields":["pubmed(457)"],"trialDetails":[{"nctId":"NCT07417761","phase":"PHASE2","title":"Tuvusertib in Astrocytoma With ATRX Mutation","status":"RECRUITING","sponsor":"Grupo Español de Investigación en Neurooncología","startDate":"2025-12-19","conditions":"Astrocytoma","enrollment":56},{"nctId":"NCT04884282","phase":"PHASE2","title":"Efficacy of Tedopi Plus Docetaxel or Tedopi Plus 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