{"id":"ozone-auto-hemotherapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Hemolysis"},{"rate":null,"effect":"Transient fever"},{"rate":null,"effect":"Chest discomfort"}]},"_chembl":{"chemblId":"CHEMBL2447938","moleculeType":"Small molecule","molecularWeight":"48.00"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The procedure is proposed to work by inducing mild oxidative stress that triggers the body's antioxidant defense systems and enhances immune function. Ozone is thought to activate white blood cells and increase oxygen delivery to tissues, potentially improving circulation and immune response. The mechanism remains incompletely characterized and is not widely accepted in conventional medicine.","oneSentence":"Ozone auto-hemotherapy involves withdrawing a patient's blood, exposing it to ozone gas, and reinfusing it to stimulate immune and antioxidant responses.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:25:12.258Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic diseases and immune-related conditions (specific indications in phase 3 trial not publicly detailed)"}]},"trialDetails":[{"nctId":"NCT04370223","phase":"PHASE3","title":"Ozone Auto-hemotherapy for COVID-19 Pneumonia","status":"UNKNOWN","sponsor":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","startDate":"2020-05-25","conditions":"COVID-19 Pneumonia","enrollment":208}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Ozone auto-hemotherapy","genericName":"Ozone auto-hemotherapy","companyName":"Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta","companyId":"institut-d-investigaci-biom-dica-de-girona-dr-josep-trueta","modality":"Biologic","firstApprovalDate":"","aiSummary":"Ozone auto-hemotherapy is a treatment that involves the use of ozone, a small molecule composed of triatomic oxygen, in a medical procedure. It has been studied as a potential treatment for COVID-19 pneumonia in a clinical trial, specifically in adults hospitalized with the condition.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}