{"id":"ozonated-olive-oil-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"}]},"_chembl":{"chemblId":"CHEMBL2107910","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ozone gas dissolved in olive oil creates a topical formulation that generates reactive oxygen species upon contact with wound tissue. These reactive species are thought to stimulate local immune responses, increase blood flow, and exert antimicrobial effects against bacteria and fungi. The oil base provides a protective barrier while allowing gradual ozone release.","oneSentence":"Ozonated olive oil gel delivers ozone and its reactive oxygen species to tissue surfaces to promote wound healing and antimicrobial activity.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:50:48.488Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue repair (Phase 3 indication presumed based on development stage)"}]},"trialDetails":[{"nctId":"NCT07184268","phase":"NA","title":"Clinical Efficacy of NST With Adjunctive Local Delivery of Ozonated Olive Versus Curcumin Gel in Stage II Grade B Periodontitis.","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-11-02","conditions":"Periodontitis, Adult","enrollment":40},{"nctId":"NCT07368114","phase":"PHASE2","title":"Validity of Ozonated Olive Oil Gel Versus Injectable Bone Graft","status":"COMPLETED","sponsor":"Suez Canal University","startDate":"2023-12-10","conditions":"Dental, Implant Osseointegration, Ozone Therapy","enrollment":16},{"nctId":"NCT06980675","phase":"NA","title":"Ozonized Olive Oil in the Treatment of Periodontal Pockets","status":"RECRUITING","sponsor":"University of Bari","startDate":"2021-10-25","conditions":"Periodontal Pocket","enrollment":20},{"nctId":"NCT05633537","phase":"NA","title":"Clinical & Radiographic Evaluation of Zinc Oxide-Ozonated Oil as a New Primary Root Canal Filling","status":"COMPLETED","sponsor":"Tanta University","startDate":"2021-07-04","conditions":"Pulp Disease, Dental, Obturation, Root Canal Infection","enrollment":90},{"nctId":"NCT05690100","phase":"NA","title":"Evaluation of the Use of Ozone Gel Versus Hyaluronic Acid Gel on Palatal Wound Healing .","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-01","conditions":"Palate; Wound","enrollment":56},{"nctId":"NCT02066337","phase":"PHASE2","title":"Effect of Ozone Gel on Treatment of Chronic Periodontitis","status":"COMPLETED","sponsor":"October 6 University","startDate":"2013-03","conditions":"Periodontal Diseases","enrollment":40}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":4,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Group II","Study Group","Ozonated olive oil gel = Oxactiv gel"],"phase":"phase_3","status":"active","brandName":"Ozonated olive oil gel","genericName":"Ozonated olive oil gel","companyName":"Suez Canal University","companyId":"suez-canal-university","modality":"Biologic","firstApprovalDate":"","aiSummary":"Ozonated olive oil gel has been studied as a potential treatment for various dental conditions, including periodontal diseases and pulp disease, in clinical trials. The exact mechanism of action of ozonated olive oil gel is currently unknown, according to ChEMBL.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}