{"id":"oxytocin-misoprostol","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Vomiting"},{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Abdominal pain"},{"rate":null,"effect":"Fever"},{"rate":null,"effect":"Flushing"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxytocin is a posterior pituitary hormone that binds to oxytocin receptors on uterine smooth muscle, triggering rhythmic contractions. Misoprostol, a prostaglandin E1 analog, sensitizes the uterus to oxytocin and independently promotes uterine contractions. Together, they provide synergistic effects for labor induction, augmentation, and management of postpartum hemorrhage.","oneSentence":"Oxytocin stimulates uterine contractions while misoprostol enhances uterine sensitivity and contractility to promote labor induction or augmentation and reduce postpartum hemorrhage.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:23.032Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Labor induction"},{"name":"Labor augmentation"},{"name":"Prevention and treatment of postpartum hemorrhage"}]},"trialDetails":[{"nctId":"NCT01113229","phase":"PHASE4","title":"Combined Use of Oxytocin and Misoprostol in the Prevention of Post Partum Haemorrhage","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-03","conditions":"Hemorrhage; Complicating Delivery","enrollment":1721},{"nctId":"NCT02910115","phase":"NA","title":"Cooling the Uterus in C-section After Dysfunctional 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