{"id":"oxytocin-low-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Flushing"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxytocin is a neuropeptide that acts on oxytocin receptors in the brain to enhance social cognition, reduce social anxiety, and promote affiliative behaviors. At low doses, it may improve interpersonal trust and reduce fear-related responses without the uterotonic effects seen at higher clinical doses. The mechanism is thought to involve modulation of amygdala activity and enhancement of social reward processing.","oneSentence":"Low-dose oxytocin binds to oxytocin receptors to modulate social bonding, trust, and prosocial behaviors, with potential therapeutic effects on social dysfunction and anxiety.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:23.355Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Social anxiety disorder"},{"name":"Autism spectrum disorder (social dysfunction)"},{"name":"Post-traumatic stress disorder (anxiety symptoms)"}]},"trialDetails":[{"nctId":"NCT07380529","phase":"NA","title":"Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients","status":"COMPLETED","sponsor":"Ankara Etlik City Hospital","startDate":"2024-10-01","conditions":"Postpartum Hemorrhage \\(PPH\\)","enrollment":300},{"nctId":"NCT05782816","phase":"PHASE4","title":"Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor","status":"COMPLETED","sponsor":"The University of Texas Medical Branch, Galveston","startDate":"2023-04-17","conditions":"Labor Long","enrollment":170},{"nctId":"NCT06990217","phase":"PHASE4","title":"Comparing High Versus Low Dose of Oxytocin, in Gravida Women With BMI 30 and Above Which Are Undergoing Induction of Labor","status":"NOT_YET_RECRUITING","sponsor":"HaEmek Medical Center, Israel","startDate":"2025-06","conditions":"Induction of Labor, Augmentation of Labor","enrollment":130},{"nctId":"NCT04000438","phase":"PHASE2","title":"Effect of Tafoxiparin on Cervical Ripening and Induction of Labor in Term Pregnant Women With an Unripe Cervix","status":"COMPLETED","sponsor":"Dilafor AB","startDate":"2019-06-21","conditions":"Labor Onset and Length Abnormalities","enrollment":365},{"nctId":"NCT05679908","phase":"PHASE2","title":"A Study to Evaluate the Efficacy and Safety of TNX-1900 in Patients With Chronic Migraine","status":"COMPLETED","sponsor":"Tonix Pharmaceuticals, Inc.","startDate":"2022-12-06","conditions":"Chronic Migraine, Chronic Migraine, Headache, Chronic Migraine Without Aura","enrollment":88},{"nctId":"NCT06789705","phase":"NA","title":"Plasma Oxytocin Changes in Response to Low-dose MDMA vs. Placebo in Patients With Arginine Vasopressin Deficiency and Healthy Controls","status":"RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2025-01-27","conditions":"Central Diabetes Insipidus","enrollment":24},{"nctId":"NCT06550089","phase":"PHASE2","title":"High Or Low Dose pOstpartUm Oxytocin at the Time of Cesarean Birth","status":"WITHDRAWN","sponsor":"University of Chicago","startDate":"2024-10","conditions":"Postpartum Hemorrhage, Pregnancy Complications, Cesarean Section Complications","enrollment":""},{"nctId":"NCT03172858","phase":"NA","title":"Randomized Control Trial of Intracervical Balloon Placement vs Oxytocin in Women With Term PROM and Unripe Cervices","status":"WITHDRAWN","sponsor":"Northwestern University","startDate":"2018-11-01","conditions":"Premature Rupture of Membrane, Unfavorable Cervix","enrollment":""},{"nctId":"NCT05179421","phase":"PHASE2","title":"Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2022-05-09","conditions":"Healthy Volunteer Study","enrollment":25},{"nctId":"NCT03260920","phase":"PHASE2","title":"Intranasal Oxytocin for Frontotemporal Dementia","status":"UNKNOWN","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2018-01-31","conditions":"Frontotemporal Dementia","enrollment":112},{"nctId":"NCT05289869","phase":"PHASE4","title":"A Pilot Study: High Versus Low Oxytocin Dosing for Induction of Labor in Pregnant Patients With Obesity","status":"COMPLETED","sponsor":"Ohio State University","startDate":"2022-04-06","conditions":"Pregnant Patients With Obesity","enrollment":20},{"nctId":"NCT02150954","phase":"PHASE4","title":"Foley Bulb With Low Dose Pitocin Versus Foley Bulb With a Standard Incremental Infusion Protocol for the Induction of Labor","status":"COMPLETED","sponsor":"Duke University","startDate":"2007-12","conditions":"Induction of Labor","enrollment":121},{"nctId":"NCT02465164","phase":"NA","title":"Cervical Ripening With Cook Catheter Plus Low Dose Oxytocin","status":"COMPLETED","sponsor":"Henry Ford Health System","startDate":"2015-07-01","conditions":"Cervical Ripening","enrollment":26},{"nctId":"NCT03434444","phase":"NA","title":"In Vitro Optimization of Oxytocin-induced Myometrial Contractility by Propranolol","status":"COMPLETED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2017-09-08","conditions":"Postpartum Hemorrhage","enrollment":57},{"nctId":"NCT03140488","phase":"PHASE4","title":"Oxytocin Dosage to Decrease Induction Duration","status":"COMPLETED","sponsor":"University of Arizona","startDate":"2017-06-05","conditions":"Obesity, Labor, Induced, Oxytocin","enrollment":140},{"nctId":"NCT05510310","phase":"PHASE1, PHASE2","title":"Breast Stimulation vs. Low Dose Oxytocin Augmentation for Labor Induction","status":"UNKNOWN","sponsor":"Western Galilee Hospital-Nahariya","startDate":"2022-10","conditions":"Labor Onset and Length Abnormalities, Uterine Rupture, Birth; Induced","enrollment":200},{"nctId":"NCT03463993","phase":"PHASE3","title":"Efficacy of Tranexamic Acid in Preventing Postpartum Haemorrhage After Elective Caesarean Section","status":"COMPLETED","sponsor":"University of Zimbabwe","startDate":"2018-04-08","conditions":"Post Partum Hemorrhage","enrollment":506},{"nctId":"NCT03604874","phase":"PHASE4","title":"High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour in Obese Women","status":"COMPLETED","sponsor":"Assiut University","startDate":"2018-09-01","conditions":"DELAYED LABOUR","enrollment":202},{"nctId":"NCT02487797","phase":"PHASE4","title":"Comparison of Low-dose and High-dose Oxytocin Regimens for Labor Augmentation","status":"COMPLETED","sponsor":"Northwestern University","startDate":"2015-09-28","conditions":"Dystocia","enrollment":1003},{"nctId":"NCT03168698","phase":"NA","title":"Carbetocin vs. Oxytocin at Elective Cesarean Section","status":"COMPLETED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2017-05-25","conditions":"Postpartum Hemorrhage","enrollment":278},{"nctId":"NCT03742531","phase":"PHASE2","title":"Does Induction Dosage in Latent Phase Affect Active Phase of Labor?","status":"COMPLETED","sponsor":"Zeynep Kamil Maternity and Pediatric Research and Training Hospital","startDate":"2018-12-15","conditions":"Oxytocin, Induction of Labor","enrollment":300},{"nctId":"NCT03001193","phase":"PHASE2","title":"Effect of Tafoxiparin to Treat Primary Slow Progress of Labor Including Prolonged Latent Phase and Labor Arrest","status":"COMPLETED","sponsor":"Dilafor AB","startDate":"2016-12","conditions":"Labor, Obstetric","enrollment":361},{"nctId":"NCT03466671","phase":"PHASE2","title":"A Trial of TTA-121 on Autism Spectrum Disorder","status":"UNKNOWN","sponsor":"Hamamatsu University","startDate":"2018-02-27","conditions":"Autism Spectrum Disorder","enrollment":144},{"nctId":"NCT01621737","phase":"NA","title":"Antipsychotic Effects of Oxytocin","status":"TERMINATED","sponsor":"University of California, San Diego","startDate":"2011-06","conditions":"Schizophrenia","enrollment":42},{"nctId":"NCT04046510","phase":"NA","title":"Comparaison of 3 Protocols of Ocytocin Administration in C Section","status":"COMPLETED","sponsor":"Mongi Slim Hospital","startDate":"2018-09-01","conditions":"Cesarean Section Complications, Oxytocin Adverse Reaction","enrollment":180},{"nctId":"NCT01587625","phase":"NA","title":"High Dose Versus Low Dose Oxytocin for Augmentation of Delayed Labour","status":"COMPLETED","sponsor":"Göteborg University","startDate":"2013-08","conditions":"Birth; Delayed","enrollment":1376},{"nctId":"NCT03085654","phase":"EARLY_PHASE1","title":"Multiple Dose Effect of Oxytocin on Males With High or Low Trait Anxiety","status":"COMPLETED","sponsor":"University of Electronic Science and Technology of China","startDate":"2017-03-03","conditions":"Healthy","enrollment":147},{"nctId":"NCT01139801","phase":"NA","title":"Cervical Ripening for Induction of Labor: Misoprostol Versus Oxytocin in Conjunction With Foley Balloon","status":"COMPLETED","sponsor":"Aultman Health Foundation","startDate":"2009-09","conditions":"Induction of Labor","enrollment":50},{"nctId":"NCT03489928","phase":"PHASE3","title":"Misoprostol Labour Induction Study","status":"COMPLETED","sponsor":"David Young","startDate":"1999-04-01","conditions":"Induction of Labour, Labour, Induced","enrollment":511},{"nctId":"NCT02318121","phase":"PHASE2","title":"Amniotomy and Oxytocin for Augmentation of Labour","status":"COMPLETED","sponsor":"Assiut University","startDate":"2014-04-01","conditions":"Prolonged Labor","enrollment":150},{"nctId":"NCT02801227","phase":"PHASE4","title":"Oxytocin vs. Prostaglandin for Induction of Labor in Primiparas With Prelabor Rupture of Membrane and Low Bishop","status":"UNKNOWN","sponsor":"Shaare Zedek Medical Center","startDate":"2016-09","conditions":"Premature Rupture of Fetal Membranes","enrollment":68},{"nctId":"NCT02063568","phase":"NA","title":"The Use of Thromboelastometry (ROTEM) to Evaluate the Changes in Coagulation With Two Different Doses of Oxytocin Following Cesarean Delivery","status":"WITHDRAWN","sponsor":"Duke University","startDate":"2015-01","conditions":"Coagulation Changes With Oxytocin","enrollment":""},{"nctId":"NCT00468520","phase":"NA","title":"Adjuvant Oxytocin for Preinduction Ripening With a Foley catheter--a Clinical Trial","status":"COMPLETED","sponsor":"Columbia University","startDate":"2003-11","conditions":"Pregnancy, Induced Labor, Cervical Ripening","enrollment":200}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":312,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Pitocin","Syntocinon"],"phase":"marketed","status":"active","brandName":"Oxytocin (Low dose)","genericName":"Oxytocin (Low dose)","companyName":"The University of Texas Medical Branch, Galveston","companyId":"the-university-of-texas-medical-branch-galveston","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Low-dose oxytocin binds to oxytocin receptors to modulate social bonding, trust, and prosocial behaviors, with potential therapeutic effects on social dysfunction and anxiety. Used for Social anxiety disorder, Autism spectrum disorder (social dysfunction), Post-traumatic stress disorder (anxiety symptoms).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}