{"id":"oxytocin-bolus-or-oxytocin-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Uterine hyperstimulation"},{"rate":null,"effect":"Maternal hypertension"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Fetal bradycardia"},{"rate":null,"effect":"Water intoxication (with prolonged infusion)"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxytocin is a neurohypophyseal hormone that acts as an agonist at oxytocin receptors, G-protein coupled receptors present on myometrial cells and lacteal tissue. Receptor activation triggers calcium influx and smooth muscle contraction, facilitating labor progression and milk letdown. Both bolus and infusion formulations are used clinically to induce or augment labor and manage postpartum hemorrhage.","oneSentence":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:35:33.672Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Labor induction"},{"name":"Labor augmentation"},{"name":"Postpartum hemorrhage prevention and treatment"},{"name":"Incomplete or inevitable abortion"}]},"trialDetails":[{"nctId":"NCT06060327","phase":"NA","title":"Comparing Tranexamic Acid Versus Ecbolics in Preventing Hemorrhage During and After Cesarean Section","status":"COMPLETED","sponsor":"Cairo University","startDate":"2023-10-15","conditions":"Postpartum Hemorrhage, Blood Loss, Postoperative, Cesarean Section Complications","enrollment":440},{"nctId":"NCT05236985","phase":"PHASE4","title":"Oxytocin Bolus Versus Infusion in Elective Cesarean Section\"","status":"RECRUITING","sponsor":"Stony Brook University","startDate":"2022-03-15","conditions":"Elective Cesarean Section","enrollment":120},{"nctId":"NCT05079061","phase":"PHASE4","title":"A Trial of Sublingual Misoprostol to Reduce Primary Postpartum Haemorrhage After Vaginal Delivery","status":"UNKNOWN","sponsor":"The University of Hong Kong","startDate":"2022-04","conditions":"Primary Postpartum Hemorrhage, Misoprostol, Delivery Complication","enrollment":1300},{"nctId":"NCT01869556","phase":"NA","title":"Comparison of IV Ergonovine With IM Carboprost, With Oxytocin IV, During Cesarean Section for Failure to Progress","status":"COMPLETED","sponsor":"Samuel Lunenfeld Research Institute, Mount Sinai Hospital","startDate":"2013-06-04","conditions":"Postpartum Hemorrhage","enrollment":105},{"nctId":"NCT02999100","phase":"PHASE1","title":"Comparison of Inhaled Oxytocin (IH) With Intramuscular (IM) Oxytocin in Pregnant Women and With Intravenous (IV) Oxytocin in Healthy Non-pregnant Women","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2016-11-23","conditions":"Postpartum Hemorrhage","enrollment":31},{"nctId":"NCT01549223","phase":"PHASE4","title":"Oxytocin And Uterotonic Agent Use For Cesarean Delivery","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2011-04","conditions":"Uterine Atony, Hypotension","enrollment":60},{"nctId":"NCT02213029","phase":"PHASE1","title":"A Study to Evaluate Pharmacokinetics, Pharmacodynamics and Tissue Concentrations of Epelsiban","status":"TERMINATED","sponsor":"GlaxoSmithKline","startDate":"2014-08-28","conditions":"Embryo Transfer","enrollment":33},{"nctId":"NCT01914419","phase":"NA","title":"Oxytocin Via Intramuscular Injection and Intravenous Bolus or Infusion for Prevention of Postpartum Hemorrhage","status":"COMPLETED","sponsor":"Gynuity Health Projects","startDate":"2014-04","conditions":"Postpartum Hemorrhage","enrollment":4983}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxytocin bolus or oxytocin infusion","genericName":"Oxytocin bolus or oxytocin infusion","companyName":"Stony Brook University","companyId":"stony-brook-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxytocin binds to oxytocin receptors on uterine smooth muscle and mammary gland tissue to stimulate contractions and milk ejection. Used for Labor induction, Labor augmentation, Postpartum hemorrhage prevention and treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}