{"id":"oxymetazoline-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Rebound congestion with prolonged use"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness or tremor (with systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding to alpha-2 adrenergic receptors on vascular smooth muscle, oxymetazoline triggers vasoconstriction that reduces blood flow and swelling in affected tissues. In gel formulation, it is applied topically to reduce nasal congestion or facial erythema by shrinking engorged blood vessels. The vasoconstrictor effect is localized to the site of application, providing symptomatic relief without systemic absorption.","oneSentence":"Oxymetazoline is a selective alpha-2 adrenergic receptor agonist that causes vasoconstriction of blood vessels in the nasal mucosa and skin.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:25.796Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion (topical gel)"},{"name":"Facial erythema / rosacea (topical gel)"}]},"trialDetails":[{"nctId":"NCT02560805","phase":"PHASE2","title":"Role of Sympathetic Overactivity and Angiotensin II in PTSD and CV","status":"SUSPENDED","sponsor":"Emory University","startDate":"2015-10","conditions":"Stress Disorders, Post-Traumatic","enrollment":134},{"nctId":"NCT05715346","phase":"PHASE1, PHASE2","title":"LEV102 Topical Gel in Acquired Blepharoptosis","status":"COMPLETED","sponsor":"Levation Pharma, Ltd.","startDate":"2023-02-23","conditions":"Acquired Blepharoptosis","enrollment":33},{"nctId":"NCT06137703","phase":"PHASE1","title":"A Study to Learn About the Study Medication, Zavegepant, in Healthy Volunteers","status":"COMPLETED","sponsor":"Pfizer","startDate":"2022-08-24","conditions":"Biological Availability","enrollment":52},{"nctId":"NCT03529487","phase":"PHASE1","title":"Intra-anal Oxymetazoline in Healthy Adult Volunteers","status":"UNKNOWN","sponsor":"RDD Pharma Ltd","startDate":"2018-08-20","conditions":"Fecal Incontinence","enrollment":40},{"nctId":"NCT02517931","phase":"NA","title":"Sphenopalatine Ganglion Block for Postdural Puncture Headache in the Emergency Department","status":"WITHDRAWN","sponsor":"University of Arkansas","startDate":"2019-01-01","conditions":"Postdural Puncture Headache","enrollment":""},{"nctId":"NCT02299557","phase":"PHASE1, PHASE2","title":"The Effect of Oxymetazoline Gel on Anal Pressure and Incontinence in Spinal Cord Injury Patients","status":"COMPLETED","sponsor":"RDD Pharma Ltd","startDate":"2014-11","conditions":"Fecal Incontinence, Spinal Cord Injury","enrollment":19},{"nctId":"NCT00420797","phase":"PHASE3","title":"A Study to Evaluate Topical Phenylephrine Gel in the Management of Faecal Incontinence","status":"WITHDRAWN","sponsor":"S.L.A. Pharma AG","startDate":"2007-02","conditions":"Faecal Incontinence","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxymetazoline gel","genericName":"Oxymetazoline gel","companyName":"RDD Pharma Ltd","companyId":"rdd-pharma-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxymetazoline is a selective alpha-2 adrenergic receptor agonist that causes vasoconstriction of blood vessels in the nasal mucosa and skin. Used for Nasal congestion (topical gel), Facial erythema / rosacea (topical gel).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}