{"id":"oxymetazoline-fluticasone-propionate","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation or dryness"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Epistaxis"},{"rate":null,"effect":"Rebound congestion (with prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxymetazoline is an alpha-2 adrenergic agonist that causes vasoconstriction, reducing blood flow and edema in nasal tissues. Fluticasone propionate is a topical corticosteroid that inhibits inflammatory mediators and immune cell activation. Together, they provide both immediate symptomatic relief and sustained anti-inflammatory benefit for nasal congestion and rhinitis.","oneSentence":"This combination nasal spray uses a decongestant to reduce nasal swelling and a corticosteroid to suppress inflammatory responses in the nasal passages.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:21.792Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion and symptoms of allergic rhinitis"},{"name":"Chronic rhinosinusitis with nasal obstruction"}]},"trialDetails":[{"nctId":"NCT02630121","phase":"PHASE4","title":"Effect of Oxymetazoline Hydrochloride in Combination With Fluticasone Propionate on the Apnea Hypopnea Index (AHI) in Subject With Persistent Nasal Congestion and Mild Obstructive Sleep Apnea","status":"RECRUITING","sponsor":"University of South Florida","startDate":"2023-04-01","conditions":"Sleep Apnea, Chronic Nasal 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Rhinitis","enrollment":64}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"oxymetazoline-fluticasone propionate","genericName":"oxymetazoline-fluticasone propionate","companyName":"Brian J Lipworth","companyId":"brian-j-lipworth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination nasal spray uses a decongestant to reduce nasal swelling and a corticosteroid to suppress inflammatory responses in the nasal passages. Used for Nasal congestion and symptoms of allergic rhinitis, Chronic rhinosinusitis with nasal obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}