{"id":"oxymetazoline-0-05-w-v","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal irritation"},{"rate":null,"effect":"Sneezing"},{"rate":null,"effect":"Rebound congestion (with prolonged use)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nervousness or tremor (systemic absorption)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"By binding to alpha-1 adrenergic receptors on vascular smooth muscle in the nasal passages, oxymetazoline causes vasoconstriction that decreases blood flow to the nasal mucosa and reduces swelling and congestion. This provides rapid symptomatic relief of nasal obstruction associated with colds, allergies, and sinusitis. The effect is topical and localized to the nasal cavity when administered as a nasal spray or solution.","oneSentence":"Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the nasal mucosa, reducing nasal congestion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:00.355Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Nasal congestion due to colds, allergies, or sinusitis"},{"name":"Temporary relief of nasal obstruction"}]},"trialDetails":[{"nctId":"NCT00487032","phase":"PHASE4","title":"Differential Adrenoreceptor Mediated Tachyphylaxis and Upregulation","status":"COMPLETED","sponsor":"Brian J Lipworth","startDate":"2008-05","conditions":"Allergic Rhinitis, Tachyphylaxis, Rhinitis Medicamentosa","enrollment":19},{"nctId":"NCT00846326","phase":"PHASE4","title":"Preventing Tolerance to Oxymetazoline in Allergic Rhinitis","status":"WITHDRAWN","sponsor":"Brian J Lipworth","startDate":"","conditions":"Allergic Rhinitis, Tachyphylaxis, Rhinitis Medicamentosa","enrollment":""},{"nctId":"NCT02154334","phase":"PHASE1","title":"Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine","status":"COMPLETED","sponsor":"Janssen Research & Development, LLC","startDate":"2014-06","conditions":"Allergic Rhinitis","enrollment":47}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxymetazoline 0.05% w/v","genericName":"Oxymetazoline 0.05% w/v","companyName":"Brian J Lipworth","companyId":"brian-j-lipworth","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxymetazoline is an alpha-1 adrenergic agonist that constricts blood vessels in the nasal mucosa, reducing nasal congestion. Used for Nasal congestion due to colds, allergies, or sinusitis, Temporary relief of nasal obstruction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}