{"id":"oxygen-pap-therapy","safety":{"commonSideEffects":[{"rate":null,"effect":"Nasal congestion or irritation"},{"rate":null,"effect":"Mask discomfort or skin breakdown"},{"rate":null,"effect":"Dry mouth or throat"},{"rate":null,"effect":"Claustrophobia or intolerance"},{"rate":null,"effect":"Oxygen toxicity (with prolonged high-concentration use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"PAP therapy (including CPAP and BiPAP) splints the airway open to prevent collapse and improve gas exchange, while supplemental oxygen increases the fraction of inspired oxygen available for absorption. Together, these modalities enhance arterial oxygen saturation and reduce the work of breathing in patients with conditions like sleep apnea, COPD, and acute respiratory failure.","oneSentence":"Oxygen therapy combined with positive airway pressure (PAP) delivers supplemental oxygen while maintaining continuous airway pressure to improve oxygenation and ventilation in patients with respiratory insufficiency.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:59:22.799Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Obstructive sleep apnea with hypoxemia"},{"name":"COPD with hypoxemic respiratory failure"},{"name":"Acute respiratory distress"},{"name":"Hypoventilation syndromes"}]},"trialDetails":[{"nctId":"NCT07056075","phase":"NA","title":"Prevention of Desaturations Using Positive Airway Pressure or Capnometry During ERCP","status":"RECRUITING","sponsor":"Karl Landsteiner University of Health Sciences","startDate":"2025-07-07","conditions":"Desaturation, Hypoxemia, ERCP","enrollment":288},{"nctId":"NCT04118387","phase":"PHASE4","title":"Central Sleep Apnea : Physiologic Mechanisms to Inform Treatment","status":"RECRUITING","sponsor":"VA Office of Research and Development","startDate":"2021-01-07","conditions":"Sleep Disordered Breathing, Able Bodied","enrollment":200},{"nctId":"NCT05754255","phase":"NA","title":"Comparison of High-flow Oxygen With or Without Nasal Positive Airway Pressure (PAP) During Propofol Sedation for Colonoscopy in an Ambulatory Surgical Center","status":"WITHDRAWN","sponsor":"Indiana University","startDate":"2023-09","conditions":"Colonoscopy, Positive-Pressure Respiration","enrollment":""},{"nctId":"NCT03824327","phase":"PHASE1","title":"Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases","status":"ACTIVE_NOT_RECRUITING","sponsor":"Ohio State University Comprehensive Cancer 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LLC.","startDate":"2025-09","conditions":"Sleep Disordered Breathing (SDB), Sleep Apnea","enrollment":150},{"nctId":"NCT07062744","phase":"NA","title":"The Role of Swan-Ganz Catheter in Hemodynamic Resuscitation for Patients With Cardiogenic Shock","status":"RECRUITING","sponsor":"Bach Mai Hospital","startDate":"2025-05-27","conditions":"Cardiogenic Shock, Pulmonary Artery Catheter Waveform Interpretation, Hemodynamic Management","enrollment":108},{"nctId":"NCT03408613","phase":"NA","title":"Obstructive Sleep Apnea and Glucose Metabolism","status":"SUSPENDED","sponsor":"University of Missouri-Columbia","startDate":"2018-01-17","conditions":"Sleep Apnea, Glucose Metabolism Disorders","enrollment":80},{"nctId":"NCT05094271","phase":"PHASE1","title":"Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?","status":"RECRUITING","sponsor":"University of California, San Diego","startDate":"2021-06-30","conditions":"OSA, Sleep Apnea, Obstructive Sleep Apnea","enrollment":260},{"nctId":"NCT04875364","phase":"PHASE2","title":"Do Endotypes Predict Response and Sequelae in OSA Patients","status":"RECRUITING","sponsor":"University of California, San Diego","startDate":"2020-08-01","conditions":"Obstructive Sleep Apnea, Sleep Apnea, Sleep Apnea, Obstructive","enrollment":200},{"nctId":"NCT06084559","phase":"NA","title":"HA Residents With PVD, Pulmonary Artery Pressure (PAP) Assessed at HA (2840m) With and Without Supplemental Oxygen Therapy (SOT)","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2023-07-05","conditions":"Pulmonary Vascular Disorder, Pulmonary Artery Hypertension, Chronic Thromboembolic Pulmonary Hypertension","enrollment":24},{"nctId":"NCT04317326","phase":"NA","title":"\"Post-acute Pickwick Study\" (Postacute-Pick-2020)","status":"WITHDRAWN","sponsor":"Juan F. Masa","startDate":"2023-01","conditions":"Acute on Chronic Hypercapnic Respiratory Failure, Obesity Hypoventilation Syndrome (OHS)","enrollment":""},{"nctId":"NCT01807897","phase":"PHASE4","title":"Oxygen Versus PAP for Sleep Apnea in Heart Failure","status":"COMPLETED","sponsor":"VA Office of Research and Development","startDate":"2014-06-23","conditions":"Heart Failure, Sleep Apnea Syndromes","enrollment":74},{"nctId":"NCT05151614","phase":"PHASE1","title":"Adjuvant Use Of Colchicine With The Standard Therapy In Moderate And Severe Corona Virus Disease-19 Infection","status":"COMPLETED","sponsor":"University of Baghdad","startDate":"2021-04-01","conditions":"COVID-19 Pandemic","enrollment":160},{"nctId":"NCT05081115","phase":"","title":"Stress Echo 2030: the Novel ABCDE-(FGLPR) Protocol to Define the Future of Imaging","status":"RECRUITING","sponsor":"Fatebenefratelli Hospital","startDate":"2021-04-01","conditions":"Coronary Artery Disease, Heart Failure, Hypertrophic Cardiomyopathy","enrollment":10000},{"nctId":"NCT04591600","phase":"PHASE1, PHASE2","title":"Effectiveness of Ivermectin and Doxycycline on COVID-19 Patients","status":"COMPLETED","sponsor":"Alkarkh Health Directorate-Baghdad","startDate":"2020-07-01","conditions":"Covid19","enrollment":140},{"nctId":"NCT01086800","phase":"PHASE2","title":"Heart Biomarker Evaluation in Apnea Treatment","status":"COMPLETED","sponsor":"Brigham and Women's Hospital","startDate":"2010-02","conditions":"Cardiovascular Disease, Obstructive Sleep Apnea, Coronary Artery Disease","enrollment":318}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":67,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Oxygen + PAP therapy","genericName":"Oxygen + PAP therapy","companyName":"VA Office of Research and Development","companyId":"va-office-of-research-and-development","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxygen therapy combined with positive airway pressure (PAP) delivers supplemental oxygen while maintaining continuous airway pressure to improve oxygenation and ventilation in patients with respiratory insufficiency. Used for Obstructive sleep apnea, Chronic obstructive pulmonary disease (COPD), Acute respiratory failure.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}