{"id":"oxycodone-acetaminophen","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"20-30","effect":"Nausea"},{"rate":"15-25","effect":"Dizziness"},{"rate":"15-25","effect":"Drowsiness"},{"rate":"10-15","effect":"Vomiting"},{"rate":"5-10","effect":"Pruritus"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hepatotoxicity (acetaminophen component)"}]},"_chembl":{"chemblId":"CHEMBL656","moleculeType":"Small molecule","molecularWeight":"315.37"},"_dailymed":{"setId":"9cbbfa94-37b9-9652-e053-2995a90a736b","title":"PROLATE (OXYCODONE AND ACETAMINOPHEN) TABLET [FORTE BIO-PHARMA LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxycodone is a semi-synthetic opioid agonist that activates mu, delta, and kappa opioid receptors, primarily in the brain and spinal cord, to modulate pain signals and produce analgesia. Acetaminophen works through a separate mechanism by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin production, providing complementary pain relief and fever reduction. The combination allows for enhanced analgesia at lower individual doses of each component.","oneSentence":"Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception, while acetaminophen inhibits prostaglandin synthesis to provide additional analgesic and antipyretic effects.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:59:17.756Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Moderate to severe chronic pain"}]},"trialDetails":[{"nctId":"NCT07435077","phase":"PHASE4","title":"Examining Analgesic Synergy and Efficacy in Trauma Care","status":"NOT_YET_RECRUITING","sponsor":"Wake Forest University Health Sciences","startDate":"2026-05","conditions":"Opioid Use Disorder","enrollment":282},{"nctId":"NCT03818932","phase":"PHASE2, PHASE3","title":"Nonopioid Analgesia After Anterior Cruciate Ligament Reconstruction","status":"COMPLETED","sponsor":"Henry Ford Health 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