{"id":"oxybuprocaine-sdu","safety":{"commonSideEffects":[{"rate":null,"effect":"Corneal epithelial toxicity"},{"rate":null,"effect":"Transient eye irritation"},{"rate":null,"effect":"Allergic conjunctivitis"}]},"_chembl":{"chemblId":"CHEMBL1200","moleculeType":"Small molecule","molecularWeight":"308.42"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Oxybuprocaine works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and the generation of action potentials. This reversible blockade of neural conduction results in local anesthesia at the site of application. It is commonly used as a topical ophthalmic anesthetic for diagnostic and minor surgical procedures.","oneSentence":"Oxybuprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:25:06.052Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Topical ophthalmic anesthesia for diagnostic procedures"},{"name":"Topical ophthalmic anesthesia for minor ocular surgery"}]},"trialDetails":[{"nctId":"NCT07230548","phase":"PHASE3","title":"Effect of Four Different Diagnostic Eye Drops on Tear Film Thickness","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2020-06-10","conditions":"Ocular Surface Disease, Tear Film Characteristics","enrollment":20}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Oxybuprocaine SDU","genericName":"Oxybuprocaine SDU","companyName":"Medical University of Vienna","companyId":"medical-university-of-vienna","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxybuprocaine is a local anesthetic that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Topical ophthalmic anesthesia for diagnostic procedures, Topical ophthalmic anesthesia for minor ocular surgery.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}