{"id":"oxophenarsine","rwe":[{"pmid":"2078419","year":"1990","title":"Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes.","finding":"","journal":"AIDS research and human retroviruses","studyType":"Clinical Study"},{"pmid":"1211922","year":"1975","title":"Drug-resistant Leptomonas: cross-resistance in trypanocide-resistant clones.","finding":"","journal":"Antimicrobial agents and chemotherapy","studyType":"Clinical Study"},{"pmid":"6020473","year":"1967","title":"Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse.","finding":"","journal":"Science (New York, N.Y.)","studyType":"Clinical Study"},{"pmid":"5969107","year":"1966","title":"Eradication of Eperythrozoon coccoides with oxophenarsine in normal and drug-resistant lines of Plasmodium berghei in mice.","finding":"","journal":"The Journal of parasitology","studyType":"Clinical Study"},{"pmid":"14332390","year":"1965","title":"SENSITIVITY TESTS FOR CANCER CHEMOTHERAPY.","finding":"","journal":"Archives of surgery (Chicago, Ill. : 1960)","studyType":"Clinical Study"}],"tags":[{"label":"oxophenarsine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"metarsen","offLabel":[],"synonyms":["oxophenarsine hydrochloride","arsenoxide","arsphenoxide","mapharsen","mapharside","metarsen","oxiarsolan","treparsen","oxophenarsine","oxophenarsine HCl"],"timeline":[],"approvals":[],"brandName":"Metarsen","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"oxophenarsine","explanation":"Think of it like a puzzle: Metarsen disrupts the process of building the instructions that cells use to grow and multiply. This can help slow down the growth of certain cells, which can be beneficial in treating diseases. However, it's a complex process, and more research is needed to fully understand how it works.","oneSentence":"Metarsen works by interfering with the production of nucleic acids in cells.","technicalDetail":"Oxophenarsine is believed to inhibit nucleic acid synthesis by interfering with the activity of enzymes involved in DNA and RNA replication, potentially leading to cytotoxic effects on rapidly dividing cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3411","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=oxophenarsine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:10:31.542661","biosimilars":[],"competitors":[],"genericName":"oxophenarsine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"QIC740F43H","CHEBI":"CHEBI:134860","INN_ID":"761","UMLSCUI":"C0069794","PUBCHEM_CID":"10845","SNOMEDCT_US":"47834000","SECONDARY_CAS_RN":"306-12-7","MESH_SUPPLEMENTAL_RECORD_UI":"C100059"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":221,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1990 Dec","pmid":"2078419","title":"Oxophenarsine, an antisyphilis drug inhibits HIV-1-specific protein synthesis in acutely and persistently infected lymphocytes.","journal":"AIDS research and human retroviruses"},{"date":"1975 Dec","pmid":"1211922","title":"Drug-resistant Leptomonas: cross-resistance in trypanocide-resistant clones.","journal":"Antimicrobial agents and chemotherapy"},{"date":"1967 Mar 24","pmid":"6020473","title":"Eperythrozoon coccoides: influence on course of infection of Plasmodium chabaudi in mouse.","journal":"Science (New York, N.Y.)"},{"date":"1966 Aug","pmid":"5969107","title":"Eradication of Eperythrozoon coccoides with oxophenarsine in normal and drug-resistant lines of Plasmodium berghei in mice.","journal":"The Journal of parasitology"},{"date":"1965 Sep","pmid":"14332390","title":"SENSITIVITY TESTS FOR CANCER CHEMOTHERAPY.","journal":"Archives of surgery (Chicago, Ill. : 1960)"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Metarsen (oxophenarsine) is a small molecule drug in the oxophenarsine class, but its target and exact mechanism of action are unknown. It is not clear if it is FDA-approved or off-patent. The approved indications for Metarsen are also unknown. As a result, its commercial status, half-life, bioavailability, and generic manufacturers are also unclear. Further research is needed to understand the safety and efficacy of Metarsen.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}