{"id":"oxilofrine","rwe":[{"pmid":"34211326","year":"2021","title":"Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.","finding":"","journal":"Journal of sports science & medicine","studyType":"Clinical Study"},{"pmid":"33755516","year":"2021","title":"Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine.","finding":"","journal":"Clinical toxicology (Philadelphia, Pa.)","studyType":"Clinical Study"},{"pmid":"29413984","year":"2018","title":"Detection and quantification of phenethylamines in sports dietary supplements by NMR approach.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"28978661","year":"2017","title":"Studies on Para-Methoxymethamphetamine (PMMA) Metabolite Pattern and Influence of CYP2D6 Genetics in Human Liver Microsomes and Authentic Samples from Fatal PMMA Intoxications.","finding":"","journal":"Drug metabolism and disposition: the biological fate of chemicals","studyType":"Clinical Study"},{"pmid":"27062112","year":"2017","title":"Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"}],"tags":[{"label":"oxilofrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":["oxilofrine","oxilofrine hydrochloride","oxilofrine HCl"],"offLabel":[],"synonyms":["oxilofrine","oxilofrine hydrochloride","oxilofrine HCl"],"timeline":[],"approvals":[],"ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"oxilofrine","explanation":"Imagine your body's nervous system as a car's accelerator and brakes. Oxilofrine is like pressing the accelerator, making your heart beat faster and your blood vessels constrict, which can increase blood pressure. This can be helpful in certain situations, but it's also important to be careful not to overdo it, as it can lead to problems like high blood pressure or heart palpitations.","oneSentence":"Oxilofrine is thought to work by stimulating the body's sympathetic nervous system, which can increase heart rate and blood pressure.","technicalDetail":"Oxilofrine is a beta-adrenergic agonist that activates the beta-1 and beta-2 adrenergic receptors, leading to increased heart rate, contractility, and cardiac output, as well as vasoconstriction and increased peripheral resistance."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3286","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OXILOFRINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:10:21.710703","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:48:48.335689+00:00","fieldsConflicting":0,"overallConfidence":0.95},"biosimilars":[],"competitors":[],"genericName":"oxilofrine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"003462","UNII":"F49638UBDR","CHEBI":"CHEBI:134822","INN_ID":"4665","RXNORM":"236554","UMLSCUI":"C0069766","ChEMBL_ID":"CHEMBL30400","KEGG_DRUG":"D08314","DRUGBANK_ID":"DB11610","PUBCHEM_CID":"688009","SECONDARY_CAS_RN":"942-51-8","MESH_SUPPLEMENTAL_RECORD_UI":"C026055"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":19,"therapeuticAreas":["Cardiovascular"],"biosimilarFilings":[],"recentPublications":[{"date":"2021 Jun","pmid":"34211326","title":"Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.","journal":"Journal of sports science & medicine"},{"date":"2021 Nov","pmid":"33755516","title":"Nine prohibited stimulants found in sports and weight loss supplements: deterenol, phenpromethamine (Vonedrine), oxilofrine, octodrine, beta-methylphenylethylamine (BMPEA), 1,3-dimethylamylamine (1,3-DMAA), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylbutylamine (1,3-DMBA) and higenamine.","journal":"Clinical toxicology (Philadelphia, Pa.)"},{"date":"2018 Mar 20","pmid":"29413984","title":"Detection and quantification of phenethylamines in sports dietary supplements by NMR approach.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2017 Dec","pmid":"28978661","title":"Studies on Para-Methoxymethamphetamine (PMMA) Metabolite Pattern and Influence of CYP2D6 Genetics in Human Liver Microsomes and Authentic Samples from Fatal PMMA Intoxications.","journal":"Drug metabolism and disposition: the biological fate of chemicals"},{"date":"2017 Jan","pmid":"27062112","title":"Pharmaceutical doses of the banned stimulant oxilofrine found in dietary supplements sold in the USA.","journal":"Drug testing and analysis"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","brandName":"OXILOFRINE","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Oxilofrine is a small molecule with the synonyms 4-Hydroxyephedrine, Carnigen, Edornat, J5.704E, Methylsympatol, and Methylsynephrin.","enrichmentLevel":5,"visitCount":1,"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T08:48:48.335689+00:00","fieldsConflicting":0,"overallConfidence":0.95},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}