{"id":"oxendolone","rwe":[{"pmid":"7513937","year":"1994","title":"[Influence of anti-androgen therapy for prostatic hypertrophy on lipid metabolism].","finding":"","journal":"Hinyokika kiyo. Acta urologica Japonica","studyType":"Clinical Study"},{"pmid":"7957162","year":"1994","title":"Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle.","finding":"","journal":"European journal of applied physiology and occupational physiology","studyType":"Clinical Study"},{"pmid":"7851809","year":"1994","title":"Antiestrogenic effects of danazol on rabbit uterus.","finding":"","journal":"Gynecologic and obstetric investigation","studyType":"Clinical Study"},{"pmid":"2278840","year":"1990","title":"Effects of antiandrogens on growth of androgen-dependent mouse mammary tumor (Shionogi carcinoma 115) in vivo and in vitro.","finding":"","journal":"The Journal of steroid biochemistry and molecular biology","studyType":"Clinical Study"},{"pmid":"2466359","year":"1989","title":"Antiandrogenic treatment of benign prostatic hyperplasia: a placebo controlled trial.","finding":"","journal":"Urological research","studyType":"Clinical Study"}],"tags":[{"label":"oxendolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"16beta-ethyl-19-nortestosterone","offLabel":[],"synonyms":["oxendolone","16beta-Ethyl-19-nortestosterone"],"timeline":[],"approvals":[],"brandName":"16Beta-Ethyl-19-Nortestosterone","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"oxendolone","explanation":"Imagine your body has a 'building plan' for muscle growth, and androgen receptors are like the blueprints. When OXENDOLONE binds to these receptors, it essentially gives the body a 'boost' to follow the plan, leading to increased muscle mass and strength.","oneSentence":"OXENDOLONE works by binding to androgen receptors in the body, triggering a cascade of events that promote muscle growth and development.","technicalDetail":"OXENDOLONE exerts its effects by binding to the androgen receptor (AR), a nuclear receptor that regulates gene expression involved in muscle growth and development. This binding event triggers a series of downstream effects, including increased protein synthesis and muscle cell proliferation, ultimately leading to enhanced muscle mass and strength."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3406","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=OXENDOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:10:11.517290","biosimilars":[],"competitors":[],"genericName":"oxendolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"MN4I850D4P","CHEBI":"CHEBI:31946","INN_ID":"4677","UMLSCUI":"C0077456","ChEMBL_ID":"CHEMBL513856","KEGG_DRUG":"D01329","PUBCHEM_CID":"443947","SNOMEDCT_US":"96374006","MESH_SUPPLEMENTAL_RECORD_UI":"C005671"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1994 Mar","pmid":"7513937","title":"[Influence of anti-androgen therapy for prostatic hypertrophy on lipid metabolism].","journal":"Hinyokika kiyo. Acta urologica Japonica"},{"date":"1994","pmid":"7957162","title":"Androgen receptor antagonist suppresses exercise-induced hypertrophy of skeletal muscle.","journal":"European journal of applied physiology and occupational physiology"},{"date":"1994","pmid":"7851809","title":"Antiestrogenic effects of danazol on rabbit uterus.","journal":"Gynecologic and obstetric investigation"},{"date":"1990 Nov 30","pmid":"2278840","title":"Effects of antiandrogens on growth of androgen-dependent mouse mammary tumor (Shionogi carcinoma 115) in vivo and in vitro.","journal":"The Journal of steroid biochemistry and molecular biology"},{"date":"1989","pmid":"2466359","title":"Antiandrogenic treatment of benign prostatic hyperplasia: a placebo controlled trial.","journal":"Urological research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"16Beta-Ethyl-19-Nortestosterone (OXENDOLONE) is a synthetic anabolic steroid classified under the oxendolone drug class. It is a small molecule modality, but its commercial status and approved indications are unknown. As a synthetic anabolic steroid, OXENDOLONE is believed to work by mimicking the effects of testosterone in the body, promoting muscle growth and development. However, its exact mechanism of action and key safety considerations are not well-documented. Further research is needed to fully understand the properties and effects of OXENDOLONE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}