{"id":"oxedrine","rwe":[{"pmid":"30000498","year":"2006","title":"Phenylephrine.","finding":"","journal":"","studyType":"Clinical Study"},{"pmid":"24554803","year":"2013","title":"Activity of the adrenergic nerve system in the airways permeability of healthy persons.","finding":"","journal":"Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH","studyType":"Clinical Study"},{"pmid":"17154352","year":"2007","title":"Detection and validated quantification of nine herbal phenalkylamines and methcathinone in human blood plasma by LC-MS/MS with electrospray ionization.","finding":"","journal":"Journal of mass spectrometry : JMS","studyType":"Clinical Study"},{"pmid":"15337824","year":"2004","title":"Citrus aurantium, an ingredient of dietary supplements marketed for weight loss: current status of clinical and basic research.","finding":"","journal":"Experimental biology and medicine (Maywood, N.J.)","studyType":"Clinical Study"},{"pmid":"7991999","year":"1993","title":"[The effect of ascorbic acid on adrenergic lipolysis].","finding":"","journal":"Sbornik lekarsky","studyType":"Clinical Study"}],"tags":[{"label":"oxedrine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Neuromedin-U receptor 2","category":"target"},{"label":"NMUR2","category":"gene"},{"label":"HTR1A","category":"gene"},{"label":"C01CA08","category":"atc"},{"label":"Active","category":"status"},{"label":"Eustachian Tube Congestion","category":"indication"},{"label":"Nasal congestion","category":"indication"},{"label":"Nasal discharge","category":"indication"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-Agonists","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Nasal Decongestants","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Respiratory System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"unknown","safety":{"contraindications":["Acidosis","Acute hepatitis","Acute pancreatitis","Angle-closure glaucoma","Arterial aneurysm","Arterial thrombosis","Arteriosclerotic vascular disease","Benign prostatic hyperplasia","Bradycardia","Chronic heart failure","Conduction disorder of the heart","Diabetes mellitus","Disorder of coronary artery","Heart disease","Hypertensive disorder","Hypertensive urgency","Hyperthyroidism","Hypoxia","Myocardial infarction","Partial atrioventricular block","Ventricular tachycardia"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"simpatol","offLabel":[],"synonyms":["p-synephrine","oxedrine hydrochloride","oxedrine tartrate","analeptin","DL-Synephrine","oxedrine","parasympatol","simpatol","sympaethamin","sympaethamine","synthenate","synephrine","oxedrine HCl"],"timeline":[],"approvals":[],"brandName":"Simpatol","ecosystem":[{"indication":"Eustachian Tube Congestion","otherDrugs":[{"name":"pseudoephedrine","slug":"pseudoephedrine","company":"Schering Plough"}],"globalPrevalence":null},{"indication":"Nasal congestion","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null},{"indication":"Nasal discharge","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":30000000}],"mechanism":{"target":"Neuromedin-U receptor 2","targets":[{"gene":"NMUR2","source":"DrugCentral","target":"Neuromedin-U receptor 2","protein":"Neuromedin-U receptor 2"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"}],"modality":"Small Molecule","drugClass":"oxedrine","explanation":"Think of it like a key fitting into a lock. Simpatol is the key that fits into the Neuromedin-U receptor 2 lock, which helps to turn off the signals that cause nasal congestion and Eustachian tube problems. 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It is a longer-acting adrenergic agent, similar to p-synephrine and m-synephrine, which are naturally occurring substances found in some plants and animals.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}